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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
H6PD
All Species:
26.67
Human Site:
Y648
Identified Species:
48.89
UniProt:
O95479
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95479
NP_004276.2
791
88893
Y648
L
Q
H
V
R
I
P
Y
Y
N
I
H
P
M
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001099298
791
88822
Y648
L
Q
H
V
R
V
P
Y
Y
N
I
H
P
M
P
Dog
Lupus familis
XP_546762
789
89091
Y646
L
R
Y
I
R
V
P
Y
Y
N
I
H
P
M
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFX1
789
88892
Y646
L
Q
H
V
R
V
P
Y
Y
N
I
H
P
M
P
Rat
Rattus norvegicus
P05370
515
59357
L390
Q
Q
C
K
R
N
E
L
V
I
R
V
Q
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513087
312
34898
E187
S
A
Q
K
L
A
V
E
L
R
S
F
F
Q
E
Chicken
Gallus gallus
XP_425746
782
88274
Y639
L
Q
N
I
R
V
P
Y
F
N
V
H
P
M
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_697820
781
88168
Y638
L
Q
H
I
R
I
P
Y
F
N
I
H
P
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12646
524
60412
V399
R
N
E
L
V
I
R
V
Q
P
G
E
A
L
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27464
522
60197
E397
S
G
E
L
K
R
S
E
L
V
M
R
V
Q
P
Sea Urchin
Strong. purpuratus
XP_795087
853
96259
Y708
L
R
Y
I
P
I
P
Y
T
N
I
H
P
M
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001150684
507
57610
F382
K
K
Q
G
R
N
E
F
V
I
R
L
Q
P
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11412
505
57503
A380
V
I
R
V
Q
P
D
A
A
V
Y
L
K
F
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
84.8
N.A.
83.4
23.1
N.A.
30.5
69.2
N.A.
53
N.A.
22.1
N.A.
22.8
39.9
Protein Similarity:
100
N.A.
98.4
91.6
N.A.
90.3
38.4
N.A.
35.4
82.3
N.A.
71.8
N.A.
37.9
N.A.
39.3
55.9
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
93.3
13.3
N.A.
0
66.6
N.A.
86.6
N.A.
6.6
N.A.
6.6
66.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
0
100
N.A.
100
N.A.
20
N.A.
26.6
86.6
Percent
Protein Identity:
N.A.
25.2
N.A.
N.A.
22.6
N.A.
Protein Similarity:
N.A.
39.7
N.A.
N.A.
36.7
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
8
8
0
0
0
8
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
16
0
0
0
16
16
0
0
0
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
8
16
0
0
8
8
8
0
% F
% Gly:
0
8
0
8
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
31
0
0
0
0
0
0
0
0
54
0
0
0
% H
% Ile:
0
8
0
31
0
31
0
0
0
16
47
0
0
0
0
% I
% Lys:
8
8
0
16
8
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
54
0
0
16
8
0
0
8
16
0
0
16
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
54
0
% M
% Asn:
0
8
8
0
0
16
0
0
0
54
0
0
0
0
16
% N
% Pro:
0
0
0
0
8
8
54
0
0
8
0
0
54
16
62
% P
% Gln:
8
47
16
0
8
0
0
0
8
0
0
0
16
16
0
% Q
% Arg:
8
16
8
0
62
8
8
0
0
8
16
8
0
0
0
% R
% Ser:
16
0
0
0
0
0
8
0
0
0
8
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
8
0
0
31
8
31
8
8
16
16
8
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
0
0
0
0
54
31
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _