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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
H6PD
All Species:
6.67
Human Site:
S425
Identified Species:
12.22
UniProt:
O95479
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95479
NP_004276.2
791
88893
S425
L
F
R
P
S
L
P
S
S
W
K
E
M
E
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001099298
791
88822
S425
L
F
R
P
S
L
P
S
S
W
K
E
M
E
G
Dog
Lupus familis
XP_546762
789
89091
K423
F
R
P
S
L
P
S
K
S
W
K
E
V
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFX1
789
88892
Q423
F
K
P
S
L
P
T
Q
K
W
K
E
V
Q
D
Rat
Rattus norvegicus
P05370
515
59357
F173
R
I
I
V
E
K
P
F
G
R
D
L
Q
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513087
312
34898
Chicken
Gallus gallus
XP_425746
782
88274
S418
F
R
P
I
M
P
K
S
T
W
R
E
V
V
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_697820
781
88168
G419
K
P
E
I
V
S
S
G
D
W
K
E
V
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12646
524
60412
A182
K
P
F
G
R
D
D
A
S
S
Q
A
L
S
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27464
522
60197
G180
V
I
I
E
K
P
F
G
H
D
L
K
S
S
C
Sea Urchin
Strong. purpuratus
XP_795087
853
96259
K484
L
R
K
P
Q
V
P
K
S
W
S
I
P
D
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001150684
507
57610
G165
M
N
P
S
S
H
P
G
W
T
R
V
I
V
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11412
505
57503
L163
E
K
P
F
G
H
D
L
A
S
A
R
E
L
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
84.8
N.A.
83.4
23.1
N.A.
30.5
69.2
N.A.
53
N.A.
22.1
N.A.
22.8
39.9
Protein Similarity:
100
N.A.
98.4
91.6
N.A.
90.3
38.4
N.A.
35.4
82.3
N.A.
71.8
N.A.
37.9
N.A.
39.3
55.9
P-Site Identity:
100
N.A.
100
40
N.A.
20
6.6
N.A.
0
26.6
N.A.
20
N.A.
6.6
N.A.
0
33.3
P-Site Similarity:
100
N.A.
100
46.6
N.A.
33.3
6.6
N.A.
0
46.6
N.A.
26.6
N.A.
26.6
N.A.
13.3
53.3
Percent
Protein Identity:
N.A.
25.2
N.A.
N.A.
22.6
N.A.
Protein Similarity:
N.A.
39.7
N.A.
N.A.
36.7
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
8
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
8
16
0
8
8
8
0
0
8
16
% D
% Glu:
8
0
8
8
8
0
0
0
0
0
0
47
8
24
16
% E
% Phe:
24
16
8
8
0
0
8
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
8
0
0
24
8
0
0
0
0
0
31
% G
% His:
0
0
0
0
0
16
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
16
16
16
0
0
0
0
0
0
0
8
8
0
0
% I
% Lys:
16
16
8
0
8
8
8
16
8
0
39
8
0
0
0
% K
% Leu:
24
0
0
0
16
16
0
8
0
0
8
8
8
8
8
% L
% Met:
8
0
0
0
8
0
0
0
0
0
0
0
16
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
16
39
24
0
31
39
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
8
0
0
8
0
0
8
0
8
8
8
% Q
% Arg:
8
24
16
0
8
0
0
0
0
8
16
8
0
0
0
% R
% Ser:
0
0
0
24
24
8
16
24
39
16
8
0
8
24
8
% S
% Thr:
0
0
0
0
0
0
8
0
8
8
0
0
0
8
0
% T
% Val:
8
0
0
8
8
8
0
0
0
0
0
8
31
16
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
54
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _