KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinector
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC2
All Species:
30.91
Human Site:
Y237
Identified Species:
48.57
UniProt:
O95347
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95347
NP_001036015.1
1197
135656
Y237
L
S
R
L
Y
I
A
Y
Q
F
L
L
A
E
D
Chimpanzee
Pan troglodytes
XP_001137286
1197
135653
Y237
L
S
R
L
Y
I
A
Y
Q
F
L
L
A
E
D
Rhesus Macaque
Macaca mulatta
XP_001110075
1197
135674
Y237
L
S
R
L
Y
I
A
Y
Q
F
L
L
A
E
D
Dog
Lupus familis
XP_538759
1191
134851
Y237
L
S
R
L
Y
I
A
Y
Q
F
L
L
A
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG48
1191
134255
Y237
L
S
R
L
Y
I
A
Y
Q
F
L
R
A
E
D
Rat
Rattus norvegicus
P97690
1191
138430
E234
I
Y
N
Q
E
L
N
E
T
R
A
K
L
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90988
1189
134923
F237
L
R
R
I
Y
V
A
F
Q
Y
V
R
A
E
E
Frog
Xenopus laevis
P50533
1203
136323
Y237
L
S
R
L
Y
V
A
Y
Q
F
V
C
A
E
E
Zebra Danio
Brachydanio rerio
NP_955836
1199
135278
Y237
L
S
R
L
Y
V
A
Y
L
F
V
C
A
E
E
Tiger Blowfish
Takifugu rubipres
NP_001027796
1200
135717
W237
L
T
R
L
H
V
A
W
L
F
V
C
A
E
E
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396284
1177
135689
W237
C
K
R
V
C
L
A
W
R
Y
V
T
A
L
N
Nematode Worm
Caenorhab. elegans
Q09591
1244
140323
F238
F
S
R
K
Y
E
A
F
Q
Y
F
Q
T
C
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002304405
1176
132657
Y237
L
K
R
F
C
I
A
Y
D
Y
V
Q
A
V
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN90
1171
132296
F237
L
K
R
F
C
V
A
F
E
Y
V
Q
A
E
K
Baker's Yeast
Sacchar. cerevisiae
P38989
1170
133910
Y237
T
E
R
I
V
V
S
Y
E
Y
Y
N
I
K
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
95.4
N.A.
91.5
22.3
N.A.
N.A.
66.8
80.7
74.4
71.1
N.A.
47.9
32.7
N.A.
Protein Similarity:
100
99.7
99.5
97.5
N.A.
95.1
46.7
N.A.
N.A.
81.9
90.2
87.4
85.4
N.A.
70.2
54.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
N.A.
46.6
73.3
66.6
46.6
N.A.
20
33.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
26.6
N.A.
N.A.
86.6
93.3
86.6
86.6
N.A.
66.6
53.3
N.A.
Percent
Protein Identity:
44.9
N.A.
N.A.
44.4
35.3
N.A.
Protein Similarity:
65.1
N.A.
N.A.
64.1
58.2
N.A.
P-Site Identity:
40
N.A.
N.A.
33.3
13.3
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
87
0
0
0
7
0
80
0
0
% A
% Cys:
7
0
0
0
20
0
0
0
0
0
0
20
0
7
0
% C
% Asp:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
34
% D
% Glu:
0
7
0
0
7
7
0
7
14
0
0
0
0
67
40
% E
% Phe:
7
0
0
14
0
0
0
20
0
54
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
0
14
0
40
0
0
0
0
0
0
7
0
0
% I
% Lys:
0
20
0
7
0
0
0
0
0
0
0
7
0
7
14
% K
% Leu:
74
0
0
54
0
14
0
0
14
0
34
27
7
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
7
0
0
0
0
7
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
54
0
0
20
0
0
0
% Q
% Arg:
0
7
94
0
0
0
0
0
7
7
0
14
0
0
0
% R
% Ser:
0
54
0
0
0
0
7
0
0
0
0
0
0
0
0
% S
% Thr:
7
7
0
0
0
0
0
0
7
0
0
7
7
0
0
% T
% Val:
0
0
0
7
7
40
0
0
0
0
47
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
14
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
60
0
0
60
0
40
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _