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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX3
All Species:
19.39
Human Site:
T318
Identified Species:
42.67
UniProt:
O95343
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95343
NP_005404.1
332
35487
T318
T
E
R
A
D
T
G
T
S
I
L
S
V
T
S
Chimpanzee
Pan troglodytes
XP_525749
487
52819
T473
T
E
R
A
D
T
G
T
S
I
L
S
V
T
S
Rhesus Macaque
Macaca mulatta
XP_001108191
360
38562
V343
I
P
G
Q
L
E
K
V
S
A
C
P
G
R
A
Dog
Lupus familis
XP_538477
580
61998
A322
A
D
V
S
G
P
D
A
A
L
M
A
R
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62233
333
35574
T319
T
E
R
A
D
T
G
T
S
I
L
S
V
T
S
Rat
Rattus norvegicus
NP_076480
337
35742
T323
T
E
R
A
D
T
G
T
S
I
L
S
V
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O42406
314
34658
T300
T
E
R
A
E
T
G
T
S
I
L
S
V
T
S
Frog
Xenopus laevis
Q7ZY13
451
48950
P416
H
S
Y
L
P
G
H
P
H
S
M
I
L
P
A
Zebra Danio
Brachydanio rerio
NP_571437
294
33139
S281
E
R
V
D
T
G
T
S
I
L
S
V
T
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23175
439
49618
E401
P
K
R
A
V
K
T
E
E
V
K
K
E
D
D
Sea Urchin
Strong. purpuratus
XP_781696
324
36468
D308
L
A
D
S
P
P
L
D
S
P
S
P
A
G
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
60.1
75.8
53
N.A.
97.3
96.7
N.A.
N.A.
89.1
20.6
82.5
N.A.
N.A.
N.A.
34.6
57.5
Protein Similarity:
100
62.2
77.7
54.4
N.A.
97.9
97.3
N.A.
N.A.
90.6
33.9
84.9
N.A.
N.A.
N.A.
46.4
65.9
P-Site Identity:
100
100
6.6
0
N.A.
100
100
N.A.
N.A.
93.3
0
6.6
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
100
100
13.3
40
N.A.
100
100
N.A.
N.A.
100
20
26.6
N.A.
N.A.
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
55
0
0
0
10
10
10
0
10
10
0
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
10
10
10
37
0
10
10
0
0
0
0
0
10
10
% D
% Glu:
10
46
0
0
10
10
0
10
10
0
0
0
10
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
10
19
46
0
0
0
0
0
10
10
10
% G
% His:
10
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
10
46
0
10
0
0
0
% I
% Lys:
0
10
0
0
0
10
10
0
0
0
10
10
0
0
0
% K
% Leu:
10
0
0
10
10
0
10
0
0
19
46
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
19
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
10
0
0
19
19
0
10
0
10
0
19
0
10
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
55
0
0
0
0
0
0
0
0
0
10
10
0
% R
% Ser:
0
10
0
19
0
0
0
10
64
10
19
46
0
10
55
% S
% Thr:
46
0
0
0
10
46
19
46
0
0
0
0
10
46
0
% T
% Val:
0
0
19
0
10
0
0
10
0
10
0
10
46
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _