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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX3
All Species:
27.58
Human Site:
T246
Identified Species:
60.67
UniProt:
O95343
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95343
NP_005404.1
332
35487
T246
L
A
Q
A
T
G
L
T
P
T
Q
V
G
N
W
Chimpanzee
Pan troglodytes
XP_525749
487
52819
T401
L
A
Q
A
T
G
L
T
P
T
Q
V
G
N
W
Rhesus Macaque
Macaca mulatta
XP_001108191
360
38562
T277
L
A
Q
A
T
G
L
T
P
T
Q
V
G
N
W
Dog
Lupus familis
XP_538477
580
61998
T250
L
A
Q
A
T
D
L
T
P
T
Q
V
G
N
W
Cat
Felis silvestris
Mouse
Mus musculus
Q62233
333
35574
T247
L
A
Q
A
T
G
L
T
P
T
Q
V
G
N
W
Rat
Rattus norvegicus
NP_076480
337
35742
T251
L
A
Q
A
T
G
L
T
P
T
Q
V
G
N
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O42406
314
34658
Q241
N
W
F
K
N
R
R
Q
R
D
R
A
A
A
A
Frog
Xenopus laevis
Q7ZY13
451
48950
T310
L
A
Q
D
T
G
L
T
I
L
Q
V
N
N
W
Zebra Danio
Brachydanio rerio
NP_571437
294
33139
R224
K
N
R
R
Q
R
D
R
A
A
A
A
K
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23175
439
49618
S288
I
D
E
P
K
D
L
S
K
S
H
I
P
K
L
Sea Urchin
Strong. purpuratus
XP_781696
324
36468
A251
R
R
Q
R
D
R
A
A
A
A
K
N
R
M
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
60.1
75.8
53
N.A.
97.3
96.7
N.A.
N.A.
89.1
20.6
82.5
N.A.
N.A.
N.A.
34.6
57.5
Protein Similarity:
100
62.2
77.7
54.4
N.A.
97.9
97.3
N.A.
N.A.
90.6
33.9
84.9
N.A.
N.A.
N.A.
46.4
65.9
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
0
73.3
6.6
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
6.6
73.3
13.3
N.A.
N.A.
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
64
0
55
0
0
10
10
19
19
10
19
10
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
10
10
19
10
0
0
10
0
0
0
0
0
% D
% Glu:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
55
0
0
0
0
0
0
55
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% I
% Lys:
10
0
0
10
10
0
0
0
10
0
10
0
10
10
0
% K
% Leu:
64
0
0
0
0
0
73
0
0
10
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
10
10
0
0
10
0
0
0
0
0
0
10
10
73
0
% N
% Pro:
0
0
0
10
0
0
0
0
55
0
0
0
10
0
0
% P
% Gln:
0
0
73
0
10
0
0
10
0
0
64
0
0
0
10
% Q
% Arg:
10
10
10
19
0
28
10
10
10
0
10
0
10
0
10
% R
% Ser:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% S
% Thr:
0
0
0
0
64
0
0
64
0
55
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
64
0
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
64
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _