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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB11
All Species:
27.88
Human Site:
Y429
Identified Species:
55.76
UniProt:
O95342
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95342
NP_003733.2
1321
146407
Y429
F
H
N
V
T
F
H
Y
P
S
R
P
E
V
K
Chimpanzee
Pan troglodytes
XP_526100
1321
146405
Y429
F
H
N
V
T
F
H
Y
P
S
R
P
E
V
K
Rhesus Macaque
Macaca mulatta
XP_001097771
1223
135558
E408
P
I
I
D
C
M
S
E
D
G
Y
K
L
D
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY30
1321
146658
Y429
F
H
N
V
T
F
H
Y
P
S
R
P
E
V
K
Rat
Rattus norvegicus
O70127
1321
146240
Y429
F
H
N
V
T
F
H
Y
P
S
R
P
D
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513897
1322
146482
Y429
F
H
N
V
T
F
R
Y
P
S
R
P
E
V
E
Chicken
Gallus gallus
XP_418636
1307
144961
Y432
F
Q
N
V
Y
F
S
Y
P
A
R
P
D
I
K
Frog
Xenopus laevis
NP_001081394
1287
141487
Y411
F
K
N
V
I
F
T
Y
P
S
R
K
D
I
Q
Zebra Danio
Brachydanio rerio
XP_001923538
1297
143408
E394
F
H
Y
P
S
R
P
E
V
K
I
L
D
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
R413
E
F
Q
D
V
F
F
R
Y
P
S
R
P
E
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
Y425
V
E
N
V
H
F
T
Y
P
S
R
P
D
V
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
D395
F
S
Y
P
A
R
P
D
E
E
I
F
D
G
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89.1
N.A.
N.A.
81.9
82.4
N.A.
76.6
49.9
49.2
69.1
N.A.
38.5
N.A.
38.2
N.A.
Protein Similarity:
100
99.5
91.2
N.A.
N.A.
90.9
91.3
N.A.
88
68.5
68.1
81.9
N.A.
58.1
N.A.
58.2
N.A.
P-Site Identity:
100
100
0
N.A.
N.A.
100
93.3
N.A.
86.6
60
53.3
13.3
N.A.
6.6
N.A.
60
N.A.
P-Site Similarity:
100
100
6.6
N.A.
N.A.
100
100
N.A.
93.3
80
73.3
26.6
N.A.
6.6
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
17
0
0
0
9
9
0
0
0
50
9
0
% D
% Glu:
9
9
0
0
0
0
0
17
9
9
0
0
34
9
9
% E
% Phe:
75
9
0
0
0
75
9
0
0
0
0
9
0
0
9
% F
% Gly:
0
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% G
% His:
0
50
0
0
9
0
34
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
9
0
9
0
0
0
0
0
17
0
0
17
0
% I
% Lys:
0
9
0
0
0
0
0
0
0
9
0
17
0
0
42
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
9
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
67
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
9
0
0
17
0
0
17
0
67
9
0
59
9
0
9
% P
% Gln:
0
9
9
0
0
0
0
0
0
0
0
0
0
9
9
% Q
% Arg:
0
0
0
0
0
17
9
9
0
0
67
9
0
0
9
% R
% Ser:
0
9
0
0
9
0
17
0
0
59
9
0
0
0
0
% S
% Thr:
0
0
0
0
42
0
17
0
0
0
0
0
0
0
0
% T
% Val:
9
0
0
67
9
0
0
0
9
0
0
0
0
50
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
17
0
9
0
0
67
9
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _