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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA8 All Species: 19.39
Human Site: T69 Identified Species: 42.67
UniProt: O94911 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94911 NP_009099.1 1581 179245 T69 M D L G R V D T F N E S R F S
Chimpanzee Pan troglodytes XP_001165971 1581 179231 T69 M D L G R V D T F N E S R F S
Rhesus Macaque Macaca mulatta XP_001082492 1581 179168 T69 T D L G R V D T F N E S R F S
Dog Lupus familis XP_548020 1622 184532 S69 M D L G P V D S F K D S L F S
Cat Felis silvestris
Mouse Mus musculus Q8K440 1620 183021 S69 K D L G R V D S F R Q S G F M
Rat Rattus norvegicus Q8CF82 1642 185792 K71 I E L S P M D K S I L S N L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 K151 T E L N P M D K S I F S K F V
Chicken Gallus gallus XP_415691 1546 175373 Y67 I V G H F M M Y M P Y P E V P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 E70 S T K E L E F E R E L P V K G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 S73 V E D V F L E S N F I K P I Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 S73 V G K G N S P S F P E V L K L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 77.1 N.A. 73.5 40.3 N.A. 39.4 46.1 N.A. 42.4 N.A. N.A. N.A. 22 N.A.
Protein Similarity: 100 99.5 97.9 85.4 N.A. 83.5 60.1 N.A. 59 63.5 N.A. 60.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 93.3 66.6 N.A. 60 20 N.A. 26.6 0 N.A. 0 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 93.3 80 N.A. 73.3 40 N.A. 46.6 13.3 N.A. 0 N.A. N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 46 10 0 0 0 64 0 0 0 10 0 0 0 0 % D
% Glu: 0 28 0 10 0 10 10 10 0 10 37 0 10 0 0 % E
% Phe: 0 0 0 0 19 0 10 0 55 10 10 0 0 55 0 % F
% Gly: 0 10 10 55 0 0 0 0 0 0 0 0 10 0 10 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 19 0 0 0 0 0 0 0 0 19 10 0 0 10 10 % I
% Lys: 10 0 19 0 0 0 0 19 0 10 0 10 10 19 0 % K
% Leu: 0 0 64 0 10 10 0 0 0 0 19 0 19 10 10 % L
% Met: 28 0 0 0 0 28 10 0 10 0 0 0 0 0 10 % M
% Asn: 0 0 0 10 10 0 0 0 10 28 0 0 10 0 0 % N
% Pro: 0 0 0 0 28 0 10 0 0 19 0 19 10 0 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 37 0 0 0 10 10 0 0 28 0 0 % R
% Ser: 10 0 0 10 0 10 0 37 19 0 0 64 0 0 37 % S
% Thr: 19 10 0 0 0 0 0 28 0 0 0 0 0 0 0 % T
% Val: 19 10 0 10 0 46 0 0 0 0 0 10 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _