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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA8 All Species: 20.3
Human Site: S856 Identified Species: 44.67
UniProt: O94911 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94911 NP_009099.1 1581 179245 S856 N S Y T W E L S P H L Y F L A
Chimpanzee Pan troglodytes XP_001165971 1581 179231 S856 N S Y T W E L S P H L Y F L A
Rhesus Macaque Macaca mulatta XP_001082492 1581 179168 S856 N S Y T W E L S P H L Y F L A
Dog Lupus familis XP_548020 1622 184532 S896 R S Y T W D L S P H L Y F L A
Cat Felis silvestris
Mouse Mus musculus Q8K440 1620 183021 S894 S S Y T W E L S P H D Y F L A
Rat Rattus norvegicus Q8CF82 1642 185792 V896 A V V P I K L V P D L Y F L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 S976 S A A P V R L S P D L Y F L K
Chicken Gallus gallus XP_415691 1546 175373 C835 S M G A W E L C S S R Y F L P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 F898 I H S P E R L F S P I Y L L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 W960 F L Y S R R N W A Q L F T Q V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 N1018 T L T T A Y F N P L L S G K G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 77.1 N.A. 73.5 40.3 N.A. 39.4 46.1 N.A. 42.4 N.A. N.A. N.A. 22 N.A.
Protein Similarity: 100 99.5 97.9 85.4 N.A. 83.5 60.1 N.A. 59 63.5 N.A. 60.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 100 86.6 N.A. 86.6 40 N.A. 46.6 40 N.A. 20 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 46.6 N.A. 60 46.6 N.A. 26.6 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 10 10 10 0 0 0 10 0 0 0 0 0 46 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 19 10 0 0 0 0 % D
% Glu: 0 0 0 0 10 46 0 0 0 0 0 0 0 0 0 % E
% Phe: 10 0 0 0 0 0 10 10 0 0 0 10 73 0 0 % F
% Gly: 0 0 10 0 0 0 0 0 0 0 0 0 10 0 10 % G
% His: 0 10 0 0 0 0 0 0 0 46 0 0 0 0 0 % H
% Ile: 10 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % I
% Lys: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 19 % K
% Leu: 0 19 0 0 0 0 82 0 0 10 73 0 10 82 0 % L
% Met: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 28 0 0 0 0 0 10 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 28 0 0 0 0 73 10 0 0 0 0 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 0 0 0 10 0 % Q
% Arg: 10 0 0 0 10 28 0 0 0 0 10 0 0 0 10 % R
% Ser: 28 46 10 10 0 0 0 55 19 10 0 10 0 0 0 % S
% Thr: 10 0 10 55 0 0 0 0 0 0 0 0 10 0 0 % T
% Val: 0 10 10 0 10 0 0 10 0 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 55 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 55 0 0 10 0 0 0 0 0 82 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _