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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA8 All Species: 40.3
Human Site: S658 Identified Species: 88.67
UniProt: O94911 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94911 NP_009099.1 1581 179245 S658 G K L K C A G S S L F L K K K
Chimpanzee Pan troglodytes XP_001165971 1581 179231 S658 G K L K C A G S S L F L K K K
Rhesus Macaque Macaca mulatta XP_001082492 1581 179168 S658 G K L K C A G S S L F L K K K
Dog Lupus familis XP_548020 1622 184532 S698 G K L K C A G S S L F L K K K
Cat Felis silvestris
Mouse Mus musculus Q8K440 1620 183021 S697 G R L K C A G S S L F L K K K
Rat Rattus norvegicus Q8CF82 1642 185792 S696 G M L K C V G S S I F L K S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 S776 G M L K C V G S S L F L K S K
Chicken Gallus gallus XP_415691 1546 175373 S640 G R L K C V G S S L F L K N K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 S699 G Q L K C V G S S L Y L K T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 T760 G K L V A S G T N Q Y L K Q K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 S765 G S L K C C G S S I F L K H H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 77.1 N.A. 73.5 40.3 N.A. 39.4 46.1 N.A. 42.4 N.A. N.A. N.A. 22 N.A.
Protein Similarity: 100 99.5 97.9 85.4 N.A. 83.5 60.1 N.A. 59 63.5 N.A. 60.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 73.3 N.A. 80 80 N.A. 73.3 N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 80 N.A. 80 86.6 N.A. 86.6 N.A. N.A. N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 46 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 91 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 82 0 0 0 0 % F
% Gly: 100 0 0 0 0 0 100 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % H
% Ile: 0 0 0 0 0 0 0 0 0 19 0 0 0 0 0 % I
% Lys: 0 46 0 91 0 0 0 0 0 0 0 0 100 46 91 % K
% Leu: 0 0 100 0 0 0 0 0 0 73 0 100 0 0 0 % L
% Met: 0 19 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 10 0 0 0 10 0 % Q
% Arg: 0 19 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 10 0 0 0 10 0 91 91 0 0 0 0 19 0 % S
% Thr: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % T
% Val: 0 0 0 10 0 37 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 19 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _