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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA8 All Species: 35.45
Human Site: S1018 Identified Species: 78
UniProt: O94911 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94911 NP_009099.1 1581 179245 S1018 A R S Q L R I S G L S P S A Y
Chimpanzee Pan troglodytes XP_001165971 1581 179231 S1018 A R S Q L R I S G L S P S A Y
Rhesus Macaque Macaca mulatta XP_001082492 1581 179168 S1018 A R S Q L R I S G L S P S A Y
Dog Lupus familis XP_548020 1622 184532 S1058 I Q S Q L R I S G L F P S A Y
Cat Felis silvestris
Mouse Mus musculus Q8K440 1620 183021 S1056 A W F Q L R V S G L F P S A Y
Rat Rattus norvegicus Q8CF82 1642 185792 S1058 A Y T Q L K L S G L L P S A Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 S1138 S Y T Q L K I S G L F P S A Y
Chicken Gallus gallus XP_415691 1546 175373 S997 A R S Q L Q V S G L L P S A Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 S1060 C R S T L R I S G L V P S A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 D1123 L L P S Q L I D V L L A P M L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 S1212 A K H Q Q L I S G V S V L S Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 77.1 N.A. 73.5 40.3 N.A. 39.4 46.1 N.A. 42.4 N.A. N.A. N.A. 22 N.A.
Protein Similarity: 100 99.5 97.9 85.4 N.A. 83.5 60.1 N.A. 59 63.5 N.A. 60.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 100 80 N.A. 73.3 66.6 N.A. 66.6 80 N.A. 80 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 80 86.6 N.A. 86.6 93.3 N.A. 80 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 64 0 0 0 0 0 0 0 0 0 0 10 0 82 0 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 28 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 91 0 0 0 0 0 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 73 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 0 0 0 19 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 10 0 0 82 19 10 0 0 91 28 0 10 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 0 0 0 0 0 0 0 82 10 0 0 % P
% Gln: 0 10 0 82 19 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 46 0 0 0 55 0 0 0 0 0 0 0 0 0 % R
% Ser: 10 0 55 10 0 0 0 91 0 0 37 0 82 10 0 % S
% Thr: 0 0 19 10 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 19 0 10 10 10 10 0 0 0 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 19 0 0 0 0 0 0 0 0 0 0 0 0 91 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _