KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACTL6B
All Species:
22.42
Human Site:
S269
Identified Species:
37.95
UniProt:
O94805
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O94805
NP_057272.1
426
46877
S269
S
V
L
Q
V
S
D
S
P
Y
D
E
Q
V
A
Chimpanzee
Pan troglodytes
XP_001140943
374
41374
V223
D
S
P
Y
D
E
Q
V
A
A
Q
M
P
T
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850533
409
44735
D258
M
C
N
E
V
I
Q
D
F
Q
A
S
V
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q99MR0
426
46873
S269
S
V
L
Q
V
S
D
S
P
Y
D
E
Q
V
A
Rat
Rattus norvegicus
NP_001034122
429
47402
S272
S
V
L
Q
V
S
D
S
T
Y
D
E
Q
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521333
303
33827
Q151
S
D
S
T
Y
D
E
Q
V
A
A
Q
M
P
T
Chicken
Gallus gallus
XP_422784
720
79965
S272
S
V
L
Q
V
S
D
S
T
Y
D
E
Q
V
A
Frog
Xenopus laevis
NP_001080451
429
47605
S272
S
V
L
Q
V
S
D
S
T
Y
D
E
Q
V
A
Zebra Danio
Brachydanio rerio
NP_775347
429
47223
S272
S
V
L
Q
V
S
D
S
P
Y
D
E
Q
V
A
Tiger Blowfish
Takifugu rubipres
P53480
377
41956
E226
C
Y
V
A
L
D
F
E
N
E
M
A
T
A
A
Fruit Fly
Dros. melanogaster
NP_611209
425
47301
Q268
Q
L
M
M
Q
D
F
Q
M
N
V
L
Q
V
L
Honey Bee
Apis mellifera
XP_625202
440
49061
D283
Q
V
S
E
T
P
Y
D
E
K
I
V
S
T
I
Nematode Worm
Caenorhab. elegans
P10986
376
41759
E225
C
Y
V
A
L
D
F
E
Q
E
M
A
T
A
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84M92
441
48918
S284
P
Y
D
D
K
S
Y
S
N
I
P
T
T
S
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.7
N.A.
93.9
N.A.
99.7
84.1
N.A.
64
52.2
83.6
83.6
36.3
57.2
60.6
36.8
N.A.
Protein Similarity:
100
87.7
N.A.
95
N.A.
100
92.5
N.A.
68.3
56.2
91.8
92.3
54.2
75.1
77.2
54.2
N.A.
P-Site Identity:
100
0
N.A.
6.6
N.A.
100
93.3
N.A.
6.6
93.3
93.3
100
6.6
13.3
6.6
6.6
N.A.
P-Site Similarity:
100
0
N.A.
20
N.A.
100
93.3
N.A.
20
93.3
93.3
100
20
26.6
13.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
0
0
0
0
8
15
15
15
0
15
58
% A
% Cys:
15
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
8
8
8
29
43
15
0
0
43
0
0
0
0
% D
% Glu:
0
0
0
15
0
8
8
15
8
15
0
43
0
0
0
% E
% Phe:
0
0
0
0
0
0
22
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
8
8
0
0
0
8
% I
% Lys:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
8
43
0
15
0
0
0
0
0
0
8
0
8
8
% L
% Met:
8
0
8
8
0
0
0
0
8
0
15
8
8
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
15
8
0
0
0
0
0
% N
% Pro:
8
0
8
0
0
8
0
0
22
0
8
0
8
8
0
% P
% Gln:
15
0
0
43
8
0
15
15
8
8
8
8
50
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
50
8
15
0
0
50
0
50
0
0
0
8
8
8
0
% S
% Thr:
0
0
0
8
8
0
0
0
22
0
0
8
22
15
8
% T
% Val:
0
50
15
0
50
0
0
8
8
0
8
8
8
50
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
22
0
8
8
0
15
0
0
43
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _