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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACTL6B
All Species:
12.73
Human Site:
S105
Identified Species:
21.54
UniProt:
O94805
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O94805
NP_057272.1
426
46877
S105
A
I
L
D
H
T
Y
S
K
H
V
K
S
E
P
Chimpanzee
Pan troglodytes
XP_001140943
374
41374
N73
L
M
S
E
A
P
W
N
T
R
A
K
R
E
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850533
409
44735
S105
A
I
L
D
H
T
Y
S
K
H
V
K
S
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q99MR0
426
46873
S105
A
I
L
D
H
T
Y
S
K
H
V
K
S
E
P
Rat
Rattus norvegicus
NP_001034122
429
47402
K108
A
I
L
D
H
T
Y
K
M
H
V
K
S
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521333
303
33827
Chicken
Gallus gallus
XP_422784
720
79965
K108
A
I
L
D
H
T
Y
K
M
H
I
K
S
E
A
Frog
Xenopus laevis
NP_001080451
429
47605
K108
A
I
I
D
H
T
Y
K
T
H
I
K
S
E
T
Zebra Danio
Brachydanio rerio
NP_775347
429
47223
K108
A
I
L
D
H
T
Y
K
M
H
F
K
S
Q
P
Tiger Blowfish
Takifugu rubipres
P53480
377
41956
G76
L
K
Y
P
I
E
H
G
I
I
T
N
W
D
D
Fruit Fly
Dros. melanogaster
NP_611209
425
47301
A113
K
V
I
D
Y
A
Y
A
N
V
I
Q
S
E
P
Honey Bee
Apis mellifera
XP_625202
440
49061
S116
K
V
L
D
Y
T
Y
S
K
V
I
Q
S
D
A
Nematode Worm
Caenorhab. elegans
P10986
376
41759
H74
T
L
K
Y
P
I
E
H
G
I
V
T
N
W
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84M92
441
48918
K115
N
I
W
E
H
A
F
K
S
C
L
M
I
D
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.7
N.A.
93.9
N.A.
99.7
84.1
N.A.
64
52.2
83.6
83.6
36.3
57.2
60.6
36.8
N.A.
Protein Similarity:
100
87.7
N.A.
95
N.A.
100
92.5
N.A.
68.3
56.2
91.8
92.3
54.2
75.1
77.2
54.2
N.A.
P-Site Identity:
100
13.3
N.A.
100
N.A.
100
80
N.A.
0
73.3
66.6
73.3
0
33.3
46.6
6.6
N.A.
P-Site Similarity:
100
40
N.A.
100
N.A.
100
80
N.A.
0
80
80
80
13.3
73.3
80
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
8
15
0
8
0
0
8
0
0
0
22
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
65
0
0
0
0
0
0
0
0
0
22
15
% D
% Glu:
0
0
0
15
0
8
8
0
0
0
0
0
0
58
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
58
0
8
8
0
50
0
0
0
0
0
% H
% Ile:
0
58
15
0
8
8
0
0
8
15
29
0
8
0
0
% I
% Lys:
15
8
8
0
0
0
0
36
29
0
0
58
0
0
8
% K
% Leu:
15
8
50
0
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
22
0
0
8
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
8
8
0
0
8
8
0
0
% N
% Pro:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
43
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
15
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% R
% Ser:
0
0
8
0
0
0
0
29
8
0
0
0
65
0
0
% S
% Thr:
8
0
0
0
0
58
0
0
15
0
8
8
0
0
8
% T
% Val:
0
15
0
0
0
0
0
0
0
15
36
0
0
0
0
% V
% Trp:
0
0
8
0
0
0
8
0
0
0
0
0
8
8
0
% W
% Tyr:
0
0
8
8
15
0
65
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _