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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TRPM2 All Species: 14.85
Human Site: T1014 Identified Species: 29.7
UniProt: O94759 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94759 NP_003298.1 1503 171198 T1014 K C P E S D A T Q Q R P A F P
Chimpanzee Pan troglodytes XP_001151930 1502 170997 T1013 K C P E S D A T Q Q R P A F P
Rhesus Macaque Macaca mulatta XP_001118347 868 97361 T405 N L P V S D I T V S L I Q Q K
Dog Lupus familis XP_544924 1096 126362 L632 Y L L F T N I L L L N L L I A
Cat Felis silvestris
Mouse Mus musculus Q91YD4 1507 172347 T1012 K C P E S D W T G Q A P A F P
Rat Rattus norvegicus Q8R455 1104 127610 E641 S S D E D L A E Q L L V Y S C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513927 1579 182519 T1001 K C P E N N E T S S E P I F P
Chicken Gallus gallus XP_422646 1509 172772 D1022 K C P E T N E D N K E P I F P
Frog Xenopus laevis NP_001155066 1139 131628 A676 Y S N D E D L A E M L L V C S
Zebra Danio Brachydanio rerio NP_001121711 1160 131872 T695 A A R S C S A T F I R V V L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster A8DYE2 2023 225520 S1124 P P C G E D P S Q P G C V T G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q93971 2032 229044 T1521 V I L G N G T T G L S C V P G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 51.7 60.5 N.A. 85 33.7 N.A. 68.3 74.2 33.3 24.7 N.A. 25.2 N.A. 22.5 N.A.
Protein Similarity: 100 99 53.3 66 N.A. 90.1 49 N.A. 77.3 85.2 48.7 40.6 N.A. 40.9 N.A. 39.1 N.A.
P-Site Identity: 100 100 26.6 0 N.A. 80 20 N.A. 53.3 46.6 6.6 20 N.A. 13.3 N.A. 6.6 N.A.
P-Site Similarity: 100 100 26.6 13.3 N.A. 80 20 N.A. 66.6 66.6 20 20 N.A. 20 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 0 0 0 0 34 9 0 0 9 0 25 0 9 % A
% Cys: 0 42 9 0 9 0 0 0 0 0 0 17 0 9 9 % C
% Asp: 0 0 9 9 9 50 0 9 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 50 17 0 17 9 9 0 17 0 0 0 0 % E
% Phe: 0 0 0 9 0 0 0 0 9 0 0 0 0 42 0 % F
% Gly: 0 0 0 17 0 9 0 0 17 0 9 0 0 0 17 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 17 0 0 9 0 9 17 9 0 % I
% Lys: 42 0 0 0 0 0 0 0 0 9 0 0 0 0 9 % K
% Leu: 0 17 17 0 0 9 9 9 9 25 25 17 9 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % M
% Asn: 9 0 9 0 17 25 0 0 9 0 9 0 0 0 0 % N
% Pro: 9 9 50 0 0 0 9 0 0 9 0 42 0 9 42 % P
% Gln: 0 0 0 0 0 0 0 0 34 25 0 0 9 9 0 % Q
% Arg: 0 0 9 0 0 0 0 0 0 0 25 0 0 0 9 % R
% Ser: 9 17 0 9 34 9 0 9 9 17 9 0 0 9 9 % S
% Thr: 0 0 0 0 17 0 9 59 0 0 0 0 0 9 0 % T
% Val: 9 0 0 9 0 0 0 0 9 0 0 17 34 0 0 % V
% Trp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % W
% Tyr: 17 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _