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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRPM2
All Species:
9.09
Human Site:
S443
Identified Species:
18.18
UniProt:
O94759
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O94759
NP_003298.1
1503
171198
S443
A
L
L
K
A
S
R
S
Q
D
H
F
G
H
E
Chimpanzee
Pan troglodytes
XP_001151930
1502
170997
S442
A
L
L
K
A
S
R
S
Q
D
H
F
G
H
E
Rhesus Macaque
Macaca mulatta
XP_001118347
868
97361
Dog
Lupus familis
XP_544924
1096
126362
H153
P
A
P
R
V
Q
M
H
H
V
A
Q
V
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q91YD4
1507
172347
S442
A
L
L
K
A
S
R
S
Q
D
H
F
G
H
E
Rat
Rattus norvegicus
Q8R455
1104
127610
M161
N
F
A
L
K
P
R
M
R
K
I
F
S
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513927
1579
182519
N431
A
L
L
K
A
S
R
N
H
D
H
F
G
H
E
Chicken
Gallus gallus
XP_422646
1509
172772
N453
A
L
F
K
A
S
R
N
Q
D
H
F
G
R
E
Frog
Xenopus laevis
NP_001155066
1139
131628
P197
A
K
N
F
S
L
K
P
R
M
R
K
I
F
S
Zebra Danio
Brachydanio rerio
NP_001121711
1160
131872
L216
G
S
I
E
I
P
V
L
C
L
L
V
H
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A8DYE2
2023
225520
K492
T
I
L
T
A
L
F
K
S
Q
H
L
S
P
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q93971
2032
229044
K686
A
I
L
T
A
L
L
K
G
Q
N
L
S
A
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
51.7
60.5
N.A.
85
33.7
N.A.
68.3
74.2
33.3
24.7
N.A.
25.2
N.A.
22.5
N.A.
Protein Similarity:
100
99
53.3
66
N.A.
90.1
49
N.A.
77.3
85.2
48.7
40.6
N.A.
40.9
N.A.
39.1
N.A.
P-Site Identity:
100
100
0
0
N.A.
100
13.3
N.A.
86.6
80
6.6
6.6
N.A.
20
N.A.
20
N.A.
P-Site Similarity:
100
100
0
6.6
N.A.
100
20
N.A.
93.3
86.6
26.6
20
N.A.
26.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
59
9
9
0
59
0
0
0
0
0
9
0
0
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
42
0
0
0
0
0
% D
% Glu:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
50
% E
% Phe:
0
9
9
9
0
0
9
0
0
0
0
50
0
9
0
% F
% Gly:
9
0
0
0
0
0
0
0
9
0
0
0
42
9
0
% G
% His:
0
0
0
0
0
0
0
9
17
0
50
0
9
34
0
% H
% Ile:
0
17
9
0
9
0
0
0
0
0
9
0
9
0
0
% I
% Lys:
0
9
0
42
9
0
9
17
0
9
0
9
0
0
0
% K
% Leu:
0
42
50
9
0
25
9
9
0
9
9
17
0
9
9
% L
% Met:
0
0
0
0
0
0
9
9
0
9
0
0
0
0
0
% M
% Asn:
9
0
9
0
0
0
0
17
0
0
9
0
0
0
0
% N
% Pro:
9
0
9
0
0
17
0
9
0
0
0
0
0
9
9
% P
% Gln:
0
0
0
0
0
9
0
0
34
17
0
9
0
0
0
% Q
% Arg:
0
0
0
9
0
0
50
0
17
0
9
0
0
17
9
% R
% Ser:
0
9
0
0
9
42
0
25
9
0
0
0
25
0
9
% S
% Thr:
9
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
9
0
9
0
0
9
0
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _