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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCO1 All Species: 6.97
Human Site: T69 Identified Species: 11.79
UniProt: O75880 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75880 NP_004580.1 301 33814 T69 L G T R P L S T A R P P P P W
Chimpanzee Pan troglodytes XP_001164786 301 33690 T69 L G T R P L S T A R P P P P W
Rhesus Macaque Macaca mulatta XP_001118271 301 33849 R69 T R P L S T A R P P P P P P W
Dog Lupus familis XP_546624 394 43433 P162 R V S T A M P P P P G S S G S
Cat Felis silvestris
Mouse Mus musculus Q5SUC9 284 31599 P52 S R A F S A G P P P P G A G P
Rat Rattus norvegicus NP_001166845 284 31750 P52 S R N F S A R P P P P G A G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423738 161 18098
Frog Xenopus laevis NP_001108271 275 31026 K41 S R H V P Q S K S F S I S S S
Zebra Danio Brachydanio rerio Q5RH02 279 32092 S38 P N T T C R S S A P P H L C A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608884 251 28157 S38 T K G K G P I S W R S L A V I
Honey Bee Apis mellifera XP_001122061 262 30294 F38 R K G N R K S F I T W K S V V
Nematode Worm Caenorhab. elegans NP_494755 312 35631 P70 T T S S P K E P P V D K N F M
Sea Urchin Strong. purpuratus XP_797763 313 34510 P78 S V S Q S P Y P Q H V L L R E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23833 295 33147 P57 R V P V G G T P I K D N G K V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 94.3 59.6 N.A. 70.4 69 N.A. N.A. 41.5 40.2 41.2 N.A. 45.8 39.8 34.9 45.6
Protein Similarity: 100 99 96 64.9 N.A. 77 76.4 N.A. N.A. 48.8 55.1 57.8 N.A. 61.4 60.4 55.1 61.9
P-Site Identity: 100 100 33.3 0 N.A. 6.6 6.6 N.A. N.A. 0 13.3 26.6 N.A. 6.6 6.6 6.6 0
P-Site Similarity: 100 100 40 13.3 N.A. 6.6 6.6 N.A. N.A. 0 20 33.3 N.A. 20 6.6 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 8 15 8 0 22 0 0 0 22 0 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 15 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % E
% Phe: 0 0 0 15 0 0 0 8 0 8 0 0 0 8 0 % F
% Gly: 0 15 15 0 15 8 8 0 0 0 8 15 8 22 0 % G
% His: 0 0 8 0 0 0 0 0 0 8 0 8 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 15 0 0 8 0 0 8 % I
% Lys: 0 15 0 8 0 15 0 8 0 8 0 15 0 8 0 % K
% Leu: 15 0 0 8 0 15 0 0 0 0 0 15 15 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 8 8 8 0 0 0 0 0 0 0 8 8 0 0 % N
% Pro: 8 0 15 0 29 15 8 43 36 36 43 22 22 22 15 % P
% Gln: 0 0 0 8 0 8 0 0 8 0 0 0 0 0 0 % Q
% Arg: 22 29 0 15 8 8 8 8 0 22 0 0 0 8 0 % R
% Ser: 29 0 22 8 29 0 36 15 8 0 15 8 22 8 15 % S
% Thr: 22 8 22 15 0 8 8 15 0 8 0 0 0 0 0 % T
% Val: 0 22 0 15 0 0 0 0 0 8 8 0 0 15 15 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 22 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _