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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SCO1
All Species:
48.48
Human Site:
S246
Identified Species:
82.05
UniProt:
O75880
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75880
NP_004580.1
301
33814
S246
R
A
Y
R
V
Y
Y
S
P
G
P
K
D
E
D
Chimpanzee
Pan troglodytes
XP_001164786
301
33690
S246
R
A
Y
R
V
Y
Y
S
P
G
P
K
D
E
D
Rhesus Macaque
Macaca mulatta
XP_001118271
301
33849
S246
R
A
Y
R
V
Y
Y
S
P
G
P
K
D
E
D
Dog
Lupus familis
XP_546624
394
43433
S339
R
A
Y
R
V
Y
Y
S
P
G
P
K
D
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q5SUC9
284
31599
S229
R
A
Y
R
V
Y
Y
S
P
G
P
K
D
E
D
Rat
Rattus norvegicus
NP_001166845
284
31750
S229
R
A
Y
R
V
Y
Y
S
P
G
P
K
D
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423738
161
18098
E107
D
P
E
R
D
S
E
E
A
I
A
R
Y
V
K
Frog
Xenopus laevis
NP_001108271
275
31026
S219
Q
E
Y
R
V
Y
Y
S
V
G
P
K
D
E
D
Zebra Danio
Brachydanio rerio
Q5RH02
279
32092
S222
R
D
F
R
V
Y
A
S
N
G
P
K
D
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608884
251
28157
S190
K
A
F
R
V
Y
F
S
A
G
P
R
D
E
D
Honey Bee
Apis mellifera
XP_001122061
262
30294
S191
K
A
Y
R
V
Y
Y
S
N
G
P
K
D
Q
D
Nematode Worm
Caenorhab. elegans
NP_494755
312
35631
S247
K
T
F
R
V
Y
H
S
Q
G
P
R
T
N
K
Sea Urchin
Strong. purpuratus
XP_797763
313
34510
S255
R
N
F
R
V
Y
Y
S
M
G
P
K
D
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23833
295
33147
S224
K
K
Y
R
V
Y
F
S
T
P
P
N
V
K
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
94.3
59.6
N.A.
70.4
69
N.A.
N.A.
41.5
40.2
41.2
N.A.
45.8
39.8
34.9
45.6
Protein Similarity:
100
99
96
64.9
N.A.
77
76.4
N.A.
N.A.
48.8
55.1
57.8
N.A.
61.4
60.4
55.1
61.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
6.6
80
73.3
N.A.
66.6
80
40
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
13.3
86.6
80
N.A.
93.3
93.3
66.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
58
0
0
0
0
8
0
15
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
8
0
0
0
0
0
0
0
79
0
79
% D
% Glu:
0
8
8
0
0
0
8
8
0
0
0
0
0
72
0
% E
% Phe:
0
0
29
0
0
0
15
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
86
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
29
8
0
0
0
0
0
0
0
0
0
72
0
8
15
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
15
0
0
8
0
8
0
% N
% Pro:
0
8
0
0
0
0
0
0
43
8
93
0
0
0
8
% P
% Gln:
8
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Q
% Arg:
58
0
0
100
0
0
0
0
0
0
0
22
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
93
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
8
0
0
0
8
0
0
% T
% Val:
0
0
0
0
93
0
0
0
8
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
65
0
0
93
65
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _