KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SC5DL
All Species:
22.12
Human Site:
S259
Identified Species:
37.44
UniProt:
O75845
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75845
NP_001020127.1
299
35301
S259
G
S
F
K
N
P
S
S
F
E
G
K
G
P
L
Chimpanzee
Pan troglodytes
XP_508825
299
35216
S259
G
S
F
K
N
P
S
S
F
E
G
K
G
P
L
Rhesus Macaque
Macaca mulatta
XP_001107388
299
35193
S259
G
S
F
K
N
P
S
S
F
E
G
K
G
P
L
Dog
Lupus familis
XP_853004
299
35489
S259
G
S
F
K
N
P
S
S
F
E
G
K
G
P
L
Cat
Felis silvestris
Mouse
Mus musculus
O88822
299
35044
S259
G
S
F
K
H
P
S
S
F
E
G
K
G
P
H
Rat
Rattus norvegicus
O35532
293
34945
R248
I
P
F
Y
T
G
A
R
H
H
D
F
H
H
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505296
299
35239
G259
G
S
F
R
S
P
S
G
F
E
G
K
G
P
L
Chicken
Gallus gallus
Q5ZLL6
296
35467
R248
V
P
F
Y
A
G
A
R
F
H
D
F
H
H
M
Frog
Xenopus laevis
NP_001087137
287
34181
D248
G
Q
Y
F
T
L
W
D
K
I
G
G
S
Y
K
Zebra Danio
Brachydanio rerio
Q7ZW77
291
34789
R248
I
P
F
Y
A
G
A
R
F
H
D
F
H
H
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793331
305
35863
S260
G
S
F
R
N
P
S
S
F
E
G
N
G
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39208
281
33124
H242
A
G
Y
H
T
I
H
H
T
T
Y
K
H
N
Y
Baker's Yeast
Sacchar. cerevisiae
P32353
365
42712
D318
G
S
Y
R
R
P
D
D
S
L
F
D
P
K
L
Red Bread Mold
Neurospora crassa
Q7SBB6
344
40644
G299
G
S
Y
R
E
P
D
G
D
M
F
A
K
E
K
Conservation
Percent
Protein Identity:
100
98.3
95.9
87.2
N.A.
83.2
27
N.A.
74.5
25.7
68.5
21.7
N.A.
N.A.
N.A.
N.A.
57.3
Protein Similarity:
100
99.6
97.6
94.3
N.A.
92.3
43.1
N.A.
88.9
43.1
81.6
41.8
N.A.
N.A.
N.A.
N.A.
73.1
P-Site Identity:
100
100
100
100
N.A.
86.6
6.6
N.A.
80
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
86.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
93.3
26.6
20
26.6
N.A.
N.A.
N.A.
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.4
39.1
42.1
Protein Similarity:
N.A.
N.A.
N.A.
50.1
56.9
59
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
20
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
15
0
22
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
15
15
8
0
22
8
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
50
0
0
0
8
0
% E
% Phe:
0
0
72
8
0
0
0
0
65
0
15
22
0
0
0
% F
% Gly:
72
8
0
0
0
22
0
15
0
0
58
8
50
0
0
% G
% His:
0
0
0
8
8
0
8
8
8
22
0
0
29
22
8
% H
% Ile:
15
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
36
0
0
0
0
8
0
0
50
8
8
15
% K
% Leu:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
22
% M
% Asn:
0
0
0
0
36
0
0
0
0
0
0
8
0
8
0
% N
% Pro:
0
22
0
0
0
65
0
0
0
0
0
0
8
50
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
29
8
0
0
22
0
0
0
0
0
0
0
% R
% Ser:
0
65
0
0
8
0
50
43
8
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
22
0
0
0
8
8
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
29
22
0
0
0
0
0
0
8
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _