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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ZMPSTE24 All Species: 30.91
Human Site: T48 Identified Species: 45.33
UniProt: O75844 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75844 NP_005848.2 475 54813 T48 Q R R I Y K T T T H V P P E L
Chimpanzee Pan troglodytes XP_513352 475 54806 T48 Q R R I Y K T T T H V P P E L
Rhesus Macaque Macaca mulatta XP_001082852 475 54874 T48 Q R R I Y K T T T H V P P E L
Dog Lupus familis XP_539577 422 48642 E32 S W T V Y L W E T F L A Q R Q
Cat Felis silvestris
Mouse Mus musculus Q80W54 475 54716 T48 Q R R I Y K T T T R V P A E L
Rat Rattus norvegicus NP_001101444 475 54829 T48 Q R R I Y K T T T H V P P E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417720 465 53514 T46 Q R R V Y R T T T H V P W E L
Frog Xenopus laevis NP_001087923 465 53504 T43 Q R K I Y R T T T H V P A E L
Zebra Danio Brachydanio rerio NP_956186 468 53723 T43 Q R K I Y R A T V H V P T E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611175 451 51621 P42 Y Q T A L K V P A E L K S H M
Honey Bee Apis mellifera XP_623864 433 51054 N43 V F M M R L T N L P K S L E G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001177479 411 47353 E21 L K D V I D N E T F E K A R L
Poplar Tree Populus trichocarpa XP_002320821 424 48433 P34 Q R A A L K L P I L P K T L V
Maize Zea mays NP_001131195 425 48732 T35 H R A L K L P T L P K P L L G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX88 424 48464 P34 Q L T A L K L P T L P K T L V
Baker's Yeast Sacchar. cerevisiae P47154 453 52306 L46 Q K L S E T K L P P V L E D E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.1 85.4 N.A. 93.4 93.6 N.A. N.A. 86.9 80.4 79.1 N.A. 48 41.8 N.A. 63.3
Protein Similarity: 100 99.7 99.5 87.1 N.A. 96 96.4 N.A. N.A. 92.2 87.3 87.7 N.A. 67.3 61 N.A. 72.8
P-Site Identity: 100 100 100 13.3 N.A. 86.6 100 N.A. N.A. 80 80 66.6 N.A. 6.6 13.3 N.A. 13.3
P-Site Similarity: 100 100 100 26.6 N.A. 86.6 100 N.A. N.A. 93.3 93.3 80 N.A. 26.6 20 N.A. 26.6
Percent
Protein Identity: 43.3 44.6 N.A. 43.5 34.7 N.A.
Protein Similarity: 59.7 61 N.A. 60.6 52.6 N.A.
P-Site Identity: 20 20 N.A. 20 13.3 N.A.
P-Site Similarity: 26.6 26.6 N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 13 19 0 0 7 0 7 0 0 7 19 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 7 0 0 0 0 0 0 0 7 0 % D
% Glu: 0 0 0 0 7 0 0 13 0 7 7 0 7 57 7 % E
% Phe: 0 7 0 0 0 0 0 0 0 13 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % G
% His: 7 0 0 0 0 0 0 0 0 44 0 0 0 7 0 % H
% Ile: 0 0 0 44 7 0 0 0 7 0 0 0 0 0 0 % I
% Lys: 0 13 13 0 7 50 7 0 0 0 13 25 0 0 0 % K
% Leu: 7 7 7 7 19 19 13 7 13 13 13 7 13 19 57 % L
% Met: 0 0 7 7 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 7 19 7 19 13 57 25 0 0 % P
% Gln: 69 7 0 0 0 0 0 0 0 0 0 0 7 0 7 % Q
% Arg: 0 63 38 0 7 19 0 0 0 7 0 0 0 13 0 % R
% Ser: 7 0 0 7 0 0 0 0 0 0 0 7 7 0 0 % S
% Thr: 0 0 19 0 0 7 50 57 63 0 0 0 19 0 0 % T
% Val: 7 0 0 19 0 0 7 0 7 0 57 0 0 0 13 % V
% Trp: 0 7 0 0 0 0 7 0 0 0 0 0 7 0 0 % W
% Tyr: 7 0 0 0 57 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _