KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA5
All Species:
17.27
Human Site:
S274
Identified Species:
25.33
UniProt:
O75582
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75582
NP_004746.2
802
89865
S274
I
S
R
R
I
L
K
S
E
P
P
Y
P
Q
E
Chimpanzee
Pan troglodytes
XP_001140389
894
100719
S366
I
S
R
R
I
L
K
S
E
P
P
Y
P
Q
E
Rhesus Macaque
Macaca mulatta
XP_001088246
1054
117436
S532
I
S
R
R
I
L
K
S
E
P
P
Y
P
Q
E
Dog
Lupus familis
XP_547953
806
90703
S281
I
S
R
R
I
L
K
S
E
P
P
Y
P
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
D280
L
Q
R
L
L
C
K
D
P
K
K
R
L
G
A
Rat
Rattus norvegicus
Q63531
735
82865
F284
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
E267
L
D
V
S
N
F
A
E
E
F
T
E
M
D
P
Chicken
Gallus gallus
Q5F3L1
789
89022
D287
I
Q
R
L
L
M
K
D
P
K
K
R
L
G
C
Frog
Xenopus laevis
P10665
733
82620
F284
A
K
L
G
M
P
Q
F
L
S
N
E
A
Q
S
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
F289
A
K
L
G
M
P
Q
F
L
S
L
E
A
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
E486
I
S
R
R
I
Q
K
E
Q
P
M
I
P
S
S
Honey Bee
Apis mellifera
XP_395099
910
102507
T292
I
S
R
R
I
L
K
T
D
P
P
I
P
S
H
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
V275
K
R
L
G
Y
N
G
V
D
E
I
K
N
H
K
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
F276
D
I
K
S
H
S
F
F
K
G
L
N
W
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
G46
L
Q
F
S
D
V
F
G
P
M
P
E
A
N
S
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
F252
R
F
L
K
I
D
V
F
A
R
I
P
S
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.1
75
93.1
N.A.
62.8
41
N.A.
82.1
89.4
40
40.5
N.A.
28.5
45.7
46.8
53.3
Protein Similarity:
100
88.5
75.1
95.1
N.A.
76.6
57.9
N.A.
86.1
94.6
57.4
57.3
N.A.
40
62.3
63
66.2
P-Site Identity:
100
100
100
100
N.A.
13.3
6.6
N.A.
6.6
20
6.6
6.6
N.A.
53.3
66.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
26.6
20
N.A.
13.3
33.3
20
20
N.A.
60
80
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.2
21.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35
38.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
0
0
0
0
7
0
7
0
0
0
25
0
7
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% C
% Asp:
7
7
0
0
7
7
0
13
13
0
0
0
0
13
7
% D
% Glu:
0
0
0
0
0
0
0
13
32
7
0
32
0
0
25
% E
% Phe:
0
7
7
0
0
7
13
32
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
25
0
0
7
7
0
7
0
0
0
13
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
7
% H
% Ile:
44
7
0
0
44
0
0
0
0
0
13
13
0
0
0
% I
% Lys:
7
19
7
7
0
0
50
0
7
13
13
7
0
0
7
% K
% Leu:
19
0
32
13
13
32
0
0
19
0
13
0
13
7
7
% L
% Met:
0
0
0
0
19
7
0
0
0
7
7
0
7
0
0
% M
% Asn:
0
0
0
0
7
7
0
0
0
0
7
7
7
7
0
% N
% Pro:
0
0
0
0
0
19
0
0
19
38
38
7
38
0
7
% P
% Gln:
0
19
0
0
0
7
19
0
7
0
0
0
0
44
0
% Q
% Arg:
7
7
50
38
0
0
0
0
0
7
0
13
0
0
0
% R
% Ser:
0
38
0
19
0
7
0
25
0
19
0
0
7
13
25
% S
% Thr:
0
0
0
0
0
0
0
7
0
0
13
0
0
0
0
% T
% Val:
0
0
7
0
0
7
7
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
25
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _