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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EED
All Species:
27.27
Human Site:
Y244
Identified Species:
50
UniProt:
O75530
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75530
NP_003788.2
441
50198
Y244
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001102402
466
53042
Y244
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Dog
Lupus familis
XP_533985
466
53042
Y244
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q921E6
441
50179
Y244
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511506
448
50852
Y251
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Chicken
Gallus gallus
Q5ZKH3
446
50359
Y249
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Frog
Xenopus laevis
Q8UUP2
438
49707
Y241
D
E
V
L
S
A
D
Y
D
L
L
G
E
K
I
Zebra Danio
Brachydanio rerio
Q566T0
443
50598
F246
D
E
V
L
S
A
D
F
D
L
L
G
E
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24338
425
47969
V232
N
M
R
G
D
R
I
V
S
S
G
M
D
H
S
Honey Bee
Apis mellifera
XP_623808
427
48821
F232
D
E
V
L
S
A
D
F
D
M
K
G
E
R
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786345
461
51844
F264
D
E
V
L
S
G
D
F
D
I
D
G
L
R
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8VZY6
379
42484
R194
F
H
P
S
D
I
E
R
F
A
S
C
G
M
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LT47
369
41239
P184
V
L
S
V
D
F
H
P
S
D
I
Y
R
F
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
94.6
94.6
N.A.
100
N.A.
N.A.
90.8
95.9
93.1
89.6
N.A.
49.8
56.2
N.A.
58.1
Protein Similarity:
100
N.A.
94.6
94.6
N.A.
100
N.A.
N.A.
92.4
97
96.1
95.2
N.A.
68.2
72.5
N.A.
73.7
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
100
100
100
93.3
N.A.
0
73.3
N.A.
60
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
100
100
100
100
N.A.
13.3
93.3
N.A.
80
Percent
Protein Identity:
N.A.
36.5
N.A.
34.6
N.A.
N.A.
Protein Similarity:
N.A.
54.4
N.A.
53
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
70
0
0
0
8
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
77
0
0
0
24
0
77
0
77
8
8
0
8
0
8
% D
% Glu:
0
77
0
0
0
0
8
0
0
0
0
0
70
0
0
% E
% Phe:
8
0
0
0
0
8
0
24
8
0
0
0
0
8
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
8
77
8
0
0
% G
% His:
0
8
0
0
0
0
8
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
8
8
0
0
8
8
0
0
0
77
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
0
0
62
0
% K
% Leu:
0
8
0
77
0
0
0
0
0
62
62
0
8
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
8
0
8
0
8
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
8
0
8
0
0
0
0
8
16
0
% R
% Ser:
0
0
8
8
77
0
0
0
16
8
8
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
77
8
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _