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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF40A
All Species:
18.18
Human Site:
Y508
Identified Species:
33.33
UniProt:
O75400
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75400
NP_060362.3
957
108805
Y508
E
R
D
R
L
E
I
Y
E
D
V
L
F
F
L
Chimpanzee
Pan troglodytes
XP_515837
972
110432
Y523
E
R
D
R
L
E
I
Y
E
D
V
L
F
F
L
Rhesus Macaque
Macaca mulatta
XP_001101626
863
97737
S461
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
W
Dog
Lupus familis
XP_533359
874
99942
V461
I
L
D
N
M
A
N
V
T
Y
S
T
T
W
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9R1C7
953
108462
Y504
E
R
D
R
L
E
I
Y
E
D
V
L
F
F
L
Rat
Rattus norvegicus
NP_001099950
953
108455
Y504
E
R
D
R
L
E
I
Y
E
D
V
L
F
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508338
855
97709
W473
K
Q
L
R
K
R
N
W
E
A
L
K
N
I
L
Chicken
Gallus gallus
NP_989492
853
96992
M481
L
K
N
I
L
D
N
M
A
N
V
T
Y
C
T
Frog
Xenopus laevis
NP_001121292
487
54707
V118
A
Q
A
V
H
P
I
V
A
A
Q
Q
A
V
S
Zebra Danio
Brachydanio rerio
NP_938170
851
97677
D467
D
E
E
L
Q
N
M
D
K
E
D
A
L
I
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608738
806
91309
K436
D
E
E
R
E
R
E
K
K
R
M
K
R
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34600
724
84646
K355
D
F
V
A
R
R
D
K
E
K
K
E
E
D
R
Sea Urchin
Strong. purpuratus
XP_001178122
1501
164734
Y787
D
R
D
R
K
D
L
Y
D
D
V
V
F
F
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
51.8
89.6
N.A.
96
96.2
N.A.
74.4
70.9
30.2
66
N.A.
41.1
N.A.
30.5
35.3
Protein Similarity:
100
98
65.6
90.6
N.A.
97.5
97.3
N.A.
78.4
75.4
36.5
74.6
N.A.
57.2
N.A.
50.2
46.5
P-Site Identity:
100
100
0
6.6
N.A.
100
100
N.A.
20
13.3
6.6
0
N.A.
6.6
N.A.
6.6
60
P-Site Similarity:
100
100
6.6
20
N.A.
100
100
N.A.
46.6
46.6
13.3
33.3
N.A.
33.3
N.A.
13.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
8
0
8
0
0
16
16
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% C
% Asp:
31
0
47
8
0
16
8
8
8
39
8
0
0
8
0
% D
% Glu:
31
16
16
0
8
31
8
0
47
8
0
8
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
8
0
39
39
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
8
0
0
39
0
0
0
0
0
0
16
0
% I
% Lys:
8
8
0
0
16
0
0
16
16
8
8
16
0
0
0
% K
% Leu:
8
8
16
8
39
0
8
0
0
0
8
31
8
0
47
% L
% Met:
0
0
0
0
8
8
8
8
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
8
0
8
24
0
0
16
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
16
0
0
8
0
0
0
0
0
8
16
0
8
8
% Q
% Arg:
0
39
0
54
8
24
0
0
0
8
0
0
8
0
8
% R
% Ser:
8
0
0
0
0
0
8
8
0
0
8
0
0
0
16
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
16
16
8
8
% T
% Val:
0
0
8
8
0
0
0
16
8
0
47
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
8
% W
% Tyr:
0
0
0
0
0
0
0
39
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _