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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF40A
All Species:
11.82
Human Site:
S352
Identified Species:
21.67
UniProt:
O75400
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75400
NP_060362.3
957
108805
S352
T
P
A
I
Q
D
Q
S
V
E
V
S
S
N
T
Chimpanzee
Pan troglodytes
XP_515837
972
110432
S367
T
P
A
I
Q
D
Q
S
V
E
V
S
S
N
T
Rhesus Macaque
Macaca mulatta
XP_001101626
863
97737
R311
S
G
L
S
W
S
N
R
E
K
A
K
Q
A
F
Dog
Lupus familis
XP_533359
874
99942
E311
T
Y
T
W
N
T
K
E
E
A
K
Q
A
F
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9R1C7
953
108462
S348
T
T
A
I
Q
D
L
S
G
D
I
S
S
N
T
Rat
Rattus norvegicus
NP_001099950
953
108455
S348
T
T
A
L
Q
D
L
S
G
D
I
S
S
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508338
855
97709
D321
Y
T
P
K
K
E
E
D
D
N
Q
P
A
K
K
Chicken
Gallus gallus
NP_989492
853
96992
K326
D
D
A
Q
P
V
K
K
T
Y
T
W
N
T
K
Frog
Xenopus laevis
NP_001121292
487
54707
Zebra Danio
Brachydanio rerio
NP_938170
851
97677
I317
E
Q
A
M
K
L
I
I
N
D
P
R
Y
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608738
806
91309
K286
A
Y
K
T
Q
K
I
K
D
E
R
E
E
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34600
724
84646
V205
T
L
A
S
M
P
N
V
P
L
P
S
E
K
K
Sea Urchin
Strong. purpuratus
XP_001178122
1501
164734
N425
I
V
N
D
P
R
Y
N
I
K
F
N
V
S
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
51.8
89.6
N.A.
96
96.2
N.A.
74.4
70.9
30.2
66
N.A.
41.1
N.A.
30.5
35.3
Protein Similarity:
100
98
65.6
90.6
N.A.
97.5
97.3
N.A.
78.4
75.4
36.5
74.6
N.A.
57.2
N.A.
50.2
46.5
P-Site Identity:
100
100
0
6.6
N.A.
66.6
60
N.A.
0
6.6
0
6.6
N.A.
13.3
N.A.
20
0
P-Site Similarity:
100
100
13.3
20
N.A.
80
80
N.A.
26.6
20
0
33.3
N.A.
20
N.A.
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
54
0
0
0
0
0
0
8
8
0
16
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
8
0
31
0
8
16
24
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
8
8
8
16
24
0
8
16
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
8
% F
% Gly:
0
8
0
0
0
0
0
0
16
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
24
0
0
16
8
8
0
16
0
0
0
0
% I
% Lys:
0
0
8
8
16
8
16
16
0
16
8
8
0
16
31
% K
% Leu:
0
8
8
8
0
8
16
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
8
0
16
8
8
8
0
8
8
31
0
% N
% Pro:
0
16
8
0
16
8
0
0
8
0
16
8
0
0
8
% P
% Gln:
0
8
0
8
39
0
16
0
0
0
8
8
8
0
0
% Q
% Arg:
0
0
0
0
0
8
0
8
0
0
8
8
0
0
8
% R
% Ser:
8
0
0
16
0
8
0
31
0
0
0
39
31
24
0
% S
% Thr:
47
24
8
8
0
8
0
0
8
0
8
0
0
8
31
% T
% Val:
0
8
0
0
0
8
0
8
16
0
16
0
8
0
0
% V
% Trp:
0
0
0
8
8
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
8
16
0
0
0
0
8
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _