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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENTPD6
All Species:
17.27
Human Site:
S238
Identified Species:
38
UniProt:
O75354
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75354
NP_001107561.1
484
53247
S238
T
I
N
F
L
T
G
S
L
K
T
P
G
G
S
Chimpanzee
Pan troglodytes
XP_514557
623
67364
S377
T
I
N
F
L
T
G
S
L
K
T
P
G
G
S
Rhesus Macaque
Macaca mulatta
XP_001099807
472
51838
S226
T
V
N
F
L
T
G
S
L
K
T
P
G
G
S
Dog
Lupus familis
XP_542683
658
71395
S413
T
V
N
F
L
T
G
S
L
K
T
P
G
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUZ9
427
47083
G190
T
G
Q
L
H
G
R
G
Q
E
T
V
G
T
L
Rat
Rattus norvegicus
Q9ER31
455
49881
S218
L
K
T
P
G
S
S
S
V
G
M
L
D
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518066
149
16186
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001089154
468
52036
S225
T
V
N
F
L
T
G
S
L
N
N
A
G
K
K
Zebra Danio
Brachydanio rerio
NP_001017862
442
49265
P204
A
L
H
G
T
E
T
P
T
V
G
M
L
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XU84
479
53825
A223
T
Y
W
P
N
N
E
A
V
F
S
E
H
V
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32621
518
56803
G232
N
Y
L
L
G
N
I
G
A
N
G
P
K
L
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76
94
62.3
N.A.
45.8
81.8
N.A.
24.7
N.A.
52.6
50.8
N.A.
N.A.
N.A.
30.9
N.A.
Protein Similarity:
100
77.3
95
67.7
N.A.
59.7
86.9
N.A.
27.4
N.A.
67.9
64.4
N.A.
N.A.
N.A.
48.7
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
20
6.6
N.A.
0
N.A.
60
0
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
26.6
20
N.A.
0
N.A.
66.6
13.3
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
30.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
10
10
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% D
% Glu:
0
0
0
0
0
10
10
0
0
10
0
10
0
0
0
% E
% Phe:
0
0
0
46
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
10
0
10
19
10
46
19
0
10
19
0
55
28
19
% G
% His:
0
0
10
0
10
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
19
0
0
0
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
37
0
0
10
10
10
% K
% Leu:
10
10
10
19
46
0
0
0
46
0
0
10
10
19
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% M
% Asn:
10
0
46
0
10
19
0
0
0
19
10
0
0
0
0
% N
% Pro:
0
0
0
19
0
0
0
10
0
0
0
46
0
0
10
% P
% Gln:
0
0
10
0
0
0
0
0
10
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
10
10
55
0
0
10
0
0
0
37
% S
% Thr:
64
0
10
0
10
46
10
0
10
0
46
0
0
10
0
% T
% Val:
0
28
0
0
0
0
0
0
19
10
0
10
0
10
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
19
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _