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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ENTPD6 All Species: 18.79
Human Site: S217 Identified Species: 41.33
UniProt: O75354 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75354 NP_001107561.1 484 53247 S217 L V G D D C V S I M N G T D E
Chimpanzee Pan troglodytes XP_514557 623 67364 S356 L V G D D C V S I M N G T D E
Rhesus Macaque Macaca mulatta XP_001099807 472 51838 S205 L V G D D C V S I M N G T D E
Dog Lupus familis XP_542683 658 71395 S392 L V G E D C V S I M N G T D E
Cat Felis silvestris
Mouse Mus musculus Q9WUZ9 427 47083 S169 S V S I M D G S Y E G I L A W
Rat Rattus norvegicus Q9ER31 455 49881 G197 I M N G T D E G V S A W I T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518066 149 16186
Chicken Gallus gallus
Frog Xenopus laevis NP_001089154 468 52036 S204 L I G K D S V S I M N G T D E
Zebra Danio Brachydanio rerio NP_001017862 442 49265 E183 S I M D G T D E G M S A W I T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XU84 479 53825 S202 H K P A A H R S V A A F D L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32621 518 56803 M211 E G D G V S I M G G D E E G V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76 94 62.3 N.A. 45.8 81.8 N.A. 24.7 N.A. 52.6 50.8 N.A. N.A. N.A. 30.9 N.A.
Protein Similarity: 100 77.3 95 67.7 N.A. 59.7 86.9 N.A. 27.4 N.A. 67.9 64.4 N.A. N.A. N.A. 48.7 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 13.3 0 N.A. 0 N.A. 80 13.3 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 13.3 20 N.A. 0 N.A. 86.6 26.6 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 10 0 0 0 0 10 19 10 0 10 0 % A
% Cys: 0 0 0 0 0 37 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 37 46 19 10 0 0 0 10 0 10 46 0 % D
% Glu: 10 0 0 10 0 0 10 10 0 10 0 10 10 0 46 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % F
% Gly: 0 10 46 19 10 0 10 10 19 10 10 46 0 10 10 % G
% His: 10 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 19 0 10 0 0 10 0 46 0 0 10 10 10 0 % I
% Lys: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 46 0 0 0 0 0 0 0 0 0 0 0 10 10 0 % L
% Met: 0 10 10 0 10 0 0 10 0 55 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 0 0 0 46 0 0 0 0 % N
% Pro: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % R
% Ser: 19 0 10 0 0 19 0 64 0 10 10 0 0 0 0 % S
% Thr: 0 0 0 0 10 10 0 0 0 0 0 0 46 10 10 % T
% Val: 0 46 0 0 10 0 46 0 19 0 0 0 0 0 19 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 10 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _