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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
23.33
Human Site:
Y65
Identified Species:
39.49
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
Y65
I
R
A
K
C
T
E
Y
L
D
R
A
E
K
L
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
Y65
I
R
A
K
C
T
E
Y
L
D
R
A
E
K
L
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
Y142
I
R
A
K
C
V
Q
Y
L
D
R
A
E
K
L
Dog
Lupus familis
XP_848812
444
49189
Y65
I
R
A
K
C
T
E
Y
L
D
R
A
E
K
L
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
Y65
I
R
A
K
C
T
E
Y
L
D
R
A
E
K
L
Rat
Rattus norvegicus
Q5XIK7
488
55183
K77
V
S
T
L
E
S
F
K
M
D
K
P
P
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
Y110
I
R
G
K
C
M
Q
Y
L
D
R
A
E
K
L
Chicken
Gallus gallus
Q1HGK7
492
56020
K71
K
H
V
K
D
I
M
K
M
L
E
S
F
K
I
Frog
Xenopus laevis
Q9PUL2
486
55412
V66
I
N
M
E
C
K
H
V
K
D
I
M
S
T
L
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
S71
E
Q
V
K
S
I
V
S
T
L
E
S
F
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
L71
Y
L
E
R
A
E
K
L
K
A
Y
L
K
K
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
V66
L
S
Q
E
Y
E
H
V
K
N
I
T
K
T
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
M65
M
N
V
K
K
A
I
M
E
E
T
E
V
V
K
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
K71
L
N
R
A
E
Q
L
K
K
H
L
E
S
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
100
86.6
100
N.A.
100
6.6
N.A.
80
13.3
26.6
13.3
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
93.3
100
N.A.
100
33.3
N.A.
86.6
33.3
33.3
33.3
N.A.
N.A.
26.6
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
36
8
8
8
0
0
0
8
0
43
0
0
0
% A
% Cys:
0
0
0
0
50
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
58
0
0
0
8
0
% D
% Glu:
8
0
8
15
15
15
29
0
8
8
15
15
43
8
8
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
15
0
8
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
0
0
0
15
0
0
8
0
0
0
0
0
% H
% Ile:
50
0
0
0
0
15
8
0
0
0
15
0
0
0
8
% I
% Lys:
8
0
0
65
8
8
8
22
29
0
8
0
15
65
8
% K
% Leu:
15
8
0
8
0
0
8
8
43
15
8
8
0
0
58
% L
% Met:
8
0
8
0
0
8
8
8
15
0
0
8
0
0
0
% M
% Asn:
0
22
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% P
% Gln:
0
8
8
0
0
8
15
0
0
0
0
0
0
0
0
% Q
% Arg:
0
43
8
8
0
0
0
0
0
0
43
0
0
0
0
% R
% Ser:
0
15
0
0
8
8
0
8
0
0
0
15
15
0
8
% S
% Thr:
0
0
8
0
0
29
0
0
8
0
8
8
0
15
0
% T
% Val:
8
0
22
0
0
8
8
15
0
0
0
0
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
8
0
0
43
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _