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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS4B
All Species:
23.64
Human Site:
S57
Identified Species:
40
UniProt:
O75351
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75351
NP_004860.2
444
49302
S57
Q
G
D
K
A
K
Q
S
I
R
A
K
C
T
E
Chimpanzee
Pan troglodytes
XP_001146376
412
45621
S57
Q
G
D
K
A
K
Q
S
I
R
A
K
C
T
E
Rhesus Macaque
Macaca mulatta
XP_001093648
516
56751
S134
H
S
D
K
A
K
E
S
I
R
A
K
C
V
Q
Dog
Lupus familis
XP_848812
444
49189
S57
Q
G
D
K
A
K
Q
S
I
R
A
K
C
T
E
Cat
Felis silvestris
Mouse
Mus musculus
P46467
444
49401
S57
Q
G
D
K
A
K
Q
S
I
R
A
K
C
T
E
Rat
Rattus norvegicus
Q5XIK7
488
55183
I69
E
Y
E
Q
V
K
S
I
V
S
T
L
E
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510255
484
54482
S102
H
S
D
K
A
K
E
S
I
R
G
K
C
M
Q
Chicken
Gallus gallus
Q1HGK7
492
56020
A63
W
Q
E
I
S
V
E
A
K
H
V
K
D
I
M
Frog
Xenopus laevis
Q9PUL2
486
55412
E58
K
W
Q
Q
V
W
Q
E
I
N
M
E
C
K
H
Zebra Danio
Brachydanio rerio
Q5U3S1
488
54873
Y63
R
Q
E
L
A
E
E
Y
E
Q
V
K
S
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393250
441
49311
Q63
S
I
R
A
K
C
T
Q
Y
L
E
R
A
E
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
O61577
516
57575
E58
Q
W
Q
T
I
R
Q
E
L
S
Q
E
Y
E
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SEX2
523
57218
W57
D
P
L
A
R
T
K
W
M
N
V
K
K
A
I
Baker's Yeast
Sacchar. cerevisiae
P52917
437
48154
Y63
I
R
A
K
F
T
E
Y
L
N
R
A
E
Q
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
70.1
96.4
N.A.
95.5
35.2
N.A.
74.1
36.3
36.4
36.4
N.A.
N.A.
75.9
N.A.
34.8
Protein Similarity:
100
92.7
79
97.5
N.A.
97.3
54.9
N.A.
83.4
54.2
54.1
54.9
N.A.
N.A.
87.8
N.A.
53.1
P-Site Identity:
100
100
66.6
100
N.A.
100
6.6
N.A.
60
6.6
20
13.3
N.A.
N.A.
0
N.A.
13.3
P-Site Similarity:
100
100
80
100
N.A.
100
40
N.A.
73.3
33.3
40
46.6
N.A.
N.A.
13.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.5
61
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.1
74.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
15
50
0
0
8
0
0
36
8
8
8
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
50
0
0
% C
% Asp:
8
0
43
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
8
0
22
0
0
8
36
15
8
0
8
15
15
15
29
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
29
0
0
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
15
0
0
0
0
0
0
0
0
8
0
0
0
0
15
% H
% Ile:
8
8
0
8
8
0
0
8
50
0
0
0
0
15
8
% I
% Lys:
8
0
0
50
8
50
8
0
8
0
0
65
8
8
8
% K
% Leu:
0
0
8
8
0
0
0
0
15
8
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
0
0
8
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
22
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
36
15
15
15
0
0
43
8
0
8
8
0
0
8
15
% Q
% Arg:
8
8
8
0
8
8
0
0
0
43
8
8
0
0
0
% R
% Ser:
8
15
0
0
8
0
8
43
0
15
0
0
8
8
0
% S
% Thr:
0
0
0
8
0
15
8
0
0
0
8
0
0
29
0
% T
% Val:
0
0
0
0
15
8
0
0
8
0
22
0
0
8
8
% V
% Trp:
8
15
0
0
0
8
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
15
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _