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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRP5
All Species:
25.45
Human Site:
Y1082
Identified Species:
50.91
UniProt:
O75197
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75197
NP_002326.2
1615
179145
Y1082
N
A
E
R
G
Y
L
Y
F
T
N
M
Q
D
R
Chimpanzee
Pan troglodytes
XP_508605
1701
188045
Y1168
N
A
E
R
G
Y
L
Y
F
T
N
M
Q
D
R
Rhesus Macaque
Macaca mulatta
XP_001117791
1209
134638
D703
G
D
F
I
Y
W
T
D
W
Q
R
R
S
I
E
Dog
Lupus familis
XP_866872
1612
180302
Y1072
N
P
E
K
G
Y
M
Y
F
T
N
L
Q
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q91VN0
1614
178879
Y1081
N
A
E
R
G
Y
M
Y
F
T
N
M
Q
D
H
Rat
Rattus norvegicus
Q9QYP1
1905
211861
Y1182
Y
H
E
M
G
F
M
Y
W
T
D
W
G
E
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508455
1480
165692
R960
A
A
L
D
G
T
E
R
E
V
L
F
F
S
G
Chicken
Gallus gallus
NP_001012915
1616
180864
Y1083
N
A
E
R
G
Y
M
Y
F
T
N
M
Q
E
R
Frog
Xenopus laevis
NP_001079163
1605
179641
Y1074
N
A
E
R
G
Y
M
Y
F
T
N
M
Q
E
R
Zebra Danio
Brachydanio rerio
XP_696943
1405
157848
T899
E
R
E
S
L
F
T
T
S
L
I
R
P
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P98163
1984
219502
D1182
W
E
C
D
G
R
I
D
C
S
D
G
S
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202408
1322
148003
D816
T
I
T
G
E
S
S
D
V
L
R
L
T
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
61.5
70
N.A.
93.9
28.4
N.A.
63.9
87.8
80.1
66.5
N.A.
20.3
N.A.
N.A.
41.6
Protein Similarity:
100
94.4
62.9
83.2
N.A.
96.4
43.3
N.A.
76.1
94
88.7
75.6
N.A.
34.8
N.A.
N.A.
54.9
P-Site Identity:
100
100
0
66.6
N.A.
86.6
26.6
N.A.
13.3
86.6
86.6
6.6
N.A.
13.3
N.A.
N.A.
0
P-Site Similarity:
100
100
13.3
93.3
N.A.
93.3
60
N.A.
13.3
100
100
13.3
N.A.
33.3
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
50
0
0
0
0
0
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
9
0
17
0
0
0
25
0
0
17
0
0
34
0
% D
% Glu:
9
9
67
0
9
0
9
0
9
0
0
0
0
34
25
% E
% Phe:
0
0
9
0
0
17
0
0
50
0
0
9
9
0
0
% F
% Gly:
9
0
0
9
75
0
0
0
0
0
0
9
9
0
9
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
9
0
9
0
0
9
0
0
0
9
0
0
9
0
% I
% Lys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
9
0
17
0
0
17
9
17
0
0
0
% L
% Met:
0
0
0
9
0
0
42
0
0
0
0
42
0
0
0
% M
% Asn:
50
0
0
0
0
0
0
0
0
0
50
0
0
0
9
% N
% Pro:
0
9
0
0
0
0
0
0
0
0
0
0
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
9
0
0
50
0
0
% Q
% Arg:
0
9
0
42
0
9
0
9
0
0
17
17
0
0
42
% R
% Ser:
0
0
0
9
0
9
9
0
9
9
0
0
17
9
0
% S
% Thr:
9
0
9
0
0
9
17
9
0
59
0
0
9
0
0
% T
% Val:
0
0
0
0
0
0
0
0
9
9
0
0
0
17
0
% V
% Trp:
9
0
0
0
0
9
0
0
17
0
0
9
0
0
0
% W
% Tyr:
9
0
0
0
9
50
0
59
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _