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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRP5
All Species:
16.36
Human Site:
S1443
Identified Species:
32.73
UniProt:
O75197
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75197
NP_002326.2
1615
179145
S1443
N
F
I
A
P
G
G
S
Q
H
G
P
F
T
G
Chimpanzee
Pan troglodytes
XP_508605
1701
188045
S1529
N
F
I
A
P
G
G
S
Q
H
G
P
F
T
G
Rhesus Macaque
Macaca mulatta
XP_001117791
1209
134638
R1038
I
L
V
F
H
S
S
R
Q
D
G
L
N
D
C
Dog
Lupus familis
XP_866872
1612
180302
S1431
L
G
Y
V
P
H
P
S
S
L
S
G
S
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q91VN0
1614
178879
S1442
N
F
I
A
P
G
G
S
Q
H
G
P
F
P
G
Rat
Rattus norvegicus
Q9QYP1
1905
211861
M1655
C
S
L
V
P
G
L
M
P
P
A
P
R
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508455
1480
165692
S1297
L
G
Y
V
P
H
P
S
S
L
S
G
S
L
P
Chicken
Gallus gallus
NP_001012915
1616
180864
S1444
N
F
I
A
P
G
S
S
Q
H
G
T
F
T
G
Frog
Xenopus laevis
NP_001079163
1605
179641
S1433
N
F
I
T
T
R
S
S
Q
P
N
T
Y
T
G
Zebra Danio
Brachydanio rerio
XP_696943
1405
157848
H1234
I
A
P
T
N
S
Q
H
G
K
G
I
S
C
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P98163
1984
219502
P1575
R
I
V
H
V
K
S
P
R
H
V
K
H
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202408
1322
148003
K1151
C
S
S
K
V
S
P
K
S
G
S
G
G
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.4
61.5
70
N.A.
93.9
28.4
N.A.
63.9
87.8
80.1
66.5
N.A.
20.3
N.A.
N.A.
41.6
Protein Similarity:
100
94.4
62.9
83.2
N.A.
96.4
43.3
N.A.
76.1
94
88.7
75.6
N.A.
34.8
N.A.
N.A.
54.9
P-Site Identity:
100
100
13.3
13.3
N.A.
93.3
20
N.A.
13.3
86.6
46.6
13.3
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
20
13.3
N.A.
93.3
26.6
N.A.
13.3
86.6
53.3
13.3
N.A.
20
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
34
0
0
0
0
0
0
9
0
0
9
9
% A
% Cys:
17
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% C
% Asp:
0
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% E
% Phe:
0
42
0
9
0
0
0
0
0
0
0
0
34
0
0
% F
% Gly:
0
17
0
0
0
42
25
0
9
9
50
25
9
0
50
% G
% His:
0
0
0
9
9
17
0
9
0
42
0
0
9
0
0
% H
% Ile:
17
9
42
0
0
0
0
0
0
0
0
9
0
0
0
% I
% Lys:
0
0
0
9
0
9
0
9
0
9
0
9
0
0
0
% K
% Leu:
17
9
9
0
0
0
9
0
0
17
0
9
0
25
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% M
% Asn:
42
0
0
0
9
0
0
0
0
0
9
0
9
0
0
% N
% Pro:
0
0
9
0
59
0
25
9
9
17
0
34
0
9
17
% P
% Gln:
0
0
0
0
0
0
9
0
50
0
0
0
0
0
0
% Q
% Arg:
9
0
0
0
0
9
0
9
9
0
0
0
9
0
0
% R
% Ser:
0
17
9
0
0
25
34
59
25
0
25
0
25
0
9
% S
% Thr:
0
0
0
17
9
0
0
0
0
0
0
17
0
34
9
% T
% Val:
0
0
17
25
17
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
17
0
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _