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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC22D2
All Species:
16.97
Human Site:
S677
Identified Species:
41.48
UniProt:
O75157
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75157
NP_055594.1
780
79228
S677
E
S
K
S
L
W
D
S
A
S
G
G
G
V
V
Chimpanzee
Pan troglodytes
XP_001138557
595
60312
K504
G
V
V
A
I
D
N
K
I
E
Q
A
M
D
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534305
769
77294
S665
E
S
K
N
L
W
D
S
A
S
G
G
G
G
V
Cat
Felis silvestris
Mouse
Mus musculus
NP_001074698
769
78179
S666
E
S
K
S
L
W
D
S
A
S
G
G
G
V
V
Rat
Rattus norvegicus
XP_574948
768
78399
S665
E
S
K
S
L
W
D
S
A
S
G
G
G
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507632
291
30570
N199
A
S
V
V
A
I
D
N
K
I
E
Q
A
M
D
Chicken
Gallus gallus
Q91012
1040
105912
S843
Q
P
P
L
V
S
T
S
I
G
M
P
V
A
P
Frog
Xenopus laevis
NP_001084750
708
73677
A617
I
D
N
K
I
E
Q
A
M
D
L
V
K
S
H
Zebra Danio
Brachydanio rerio
NP_956403
556
58684
A465
I
D
N
K
I
E
Q
A
M
D
L
V
K
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24523
1206
124784
S1034
N
A
E
S
E
T
E
S
A
S
G
T
S
A
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.5
N.A.
86.4
N.A.
84.7
83.5
N.A.
29.1
25.2
51.2
38.8
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
75.7
N.A.
90.1
N.A.
88.3
87.4
N.A.
33
38.2
62.3
50
N.A.
32.9
N.A.
N.A.
N.A.
P-Site Identity:
100
0
N.A.
86.6
N.A.
100
100
N.A.
13.3
6.6
0
0
N.A.
40
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
N.A.
93.3
N.A.
100
100
N.A.
26.6
20
13.3
13.3
N.A.
60
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
10
10
0
0
20
50
0
0
10
10
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
0
0
0
10
50
0
0
20
0
0
0
10
10
% D
% Glu:
40
0
10
0
10
20
10
0
0
10
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
10
50
40
40
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% H
% Ile:
20
0
0
0
30
10
0
0
20
10
0
0
0
0
0
% I
% Lys:
0
0
40
20
0
0
0
10
10
0
0
0
20
0
0
% K
% Leu:
0
0
0
10
40
0
0
0
0
0
20
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
20
0
10
0
10
10
0
% M
% Asn:
10
0
20
10
0
0
10
10
0
0
0
0
0
0
0
% N
% Pro:
0
10
10
0
0
0
0
0
0
0
0
10
0
0
10
% P
% Gln:
10
0
0
0
0
0
20
0
0
0
10
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
50
0
40
0
10
0
60
0
50
0
0
10
20
0
% S
% Thr:
0
0
0
0
0
10
10
0
0
0
0
10
0
0
0
% T
% Val:
0
10
20
10
10
0
0
0
0
0
0
20
10
30
50
% V
% Trp:
0
0
0
0
0
40
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _