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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMCC2
All Species:
11.52
Human Site:
S221
Identified Species:
28.15
UniProt:
O75069
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75069
NP_055673.2
709
77449
S221
H
Q
C
R
P
R
S
S
S
T
T
D
T
A
L
Chimpanzee
Pan troglodytes
XP_001160985
709
77437
S221
H
Q
C
R
P
R
S
S
S
T
T
D
T
A
L
Rhesus Macaque
Macaca mulatta
XP_001094601
710
77482
S222
H
Q
C
R
P
R
S
S
S
T
T
D
T
A
L
Dog
Lupus familis
XP_545686
723
78887
P230
L
H
Q
H
Q
C
R
P
R
S
S
S
T
T
D
Cat
Felis silvestris
Mouse
Mus musculus
Q80W04
706
77036
T221
R
S
S
S
T
T
D
T
A
L
L
L
A
D
G
Rat
Rattus norvegicus
XP_223107
706
77125
T221
R
S
S
S
T
T
D
T
A
L
L
L
A
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507743
649
70745
L221
E
G
S
S
V
Y
F
L
A
E
E
S
E
G
L
Chicken
Gallus gallus
XP_417961
686
75701
T217
S
G
A
V
Y
L
L
T
E
D
S
E
S
L
A
Frog
Xenopus laevis
NP_001084767
509
55651
Q87
A
A
I
L
Q
L
Q
Q
K
I
L
K
L
T
E
Zebra Danio
Brachydanio rerio
NP_001038384
467
51336
H44
R
T
R
A
A
L
E
H
L
Q
Q
K
I
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99
95
N.A.
94.5
94.2
N.A.
76.7
82.7
47.1
52.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
99.3
95.5
N.A.
96.4
95.9
N.A.
81
87
56.9
58.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
0
0
N.A.
6.6
0
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
13.3
13.3
N.A.
13.3
26.6
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
10
10
0
0
0
30
0
0
0
20
30
10
% A
% Cys:
0
0
30
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
20
0
0
10
0
30
0
20
10
% D
% Glu:
10
0
0
0
0
0
10
0
10
10
10
10
10
0
10
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
20
0
0
0
0
0
0
0
0
0
0
0
10
20
% G
% His:
30
10
0
10
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
10
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
20
0
0
10
% K
% Leu:
10
0
0
10
0
30
10
10
10
20
30
20
10
20
40
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
30
0
0
10
0
0
0
0
0
0
0
% P
% Gln:
0
30
10
0
20
0
10
10
0
10
10
0
0
0
0
% Q
% Arg:
30
0
10
30
0
30
10
0
10
0
0
0
0
0
0
% R
% Ser:
10
20
30
30
0
0
30
30
30
10
20
20
10
0
0
% S
% Thr:
0
10
0
0
20
20
0
30
0
30
30
0
40
20
0
% T
% Val:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _