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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5B
All Species:
44.55
Human Site:
T816
Identified Species:
70
UniProt:
O60841
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60841
NP_056988.3
1220
138827
T816
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Chimpanzee
Pan troglodytes
XP_001159716
1220
138677
T816
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Rhesus Macaque
Macaca mulatta
XP_001103720
1526
171398
T1122
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Dog
Lupus familis
XP_851262
1220
138726
T816
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q05D44
1216
137597
T812
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Rat
Rattus norvegicus
B2GUV7
1216
137668
T812
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507187
1282
144754
T878
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Chicken
Gallus gallus
NP_001033585
1220
137737
T816
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923573
1166
130209
T762
Y
E
N
K
D
P
R
T
F
V
S
L
V
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651974
1144
127185
T740
Y
E
N
T
D
P
K
T
Y
I
S
L
V
P
T
Honey Bee
Apis mellifera
XP_392101
1028
116618
Q665
L
M
Y
S
E
E
L
Q
A
T
V
L
E
V
K
Nematode Worm
Caenorhab. elegans
NP_497536
1074
120399
D670
H
K
N
A
E
D
S
D
Y
V
C
M
V
P
T
Sea Urchin
Strong. purpuratus
XP_001199006
1349
151384
T945
N
D
N
P
D
P
K
T
Y
I
S
L
V
P
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177807
1294
142098
D888
Y
K
N
K
D
M
G
D
T
F
S
I
V
P
T
Baker's Yeast
Sacchar. cerevisiae
P39730
1002
112250
E658
L
S
N
G
Y
L
R
E
G
D
R
I
V
L
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
79.2
96
N.A.
91.6
90
N.A.
82.2
84.5
N.A.
64.3
N.A.
50.8
53.6
40.3
43.5
Protein Similarity:
100
99.7
79.7
97.8
N.A.
95.1
94.5
N.A.
87.6
90.5
N.A.
75.4
N.A.
66.7
67.7
61.1
62.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
73.3
6.6
33.3
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
93.3
13.3
66.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.3
39.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.9
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% C
% Asp:
0
7
0
0
80
7
0
14
0
7
0
0
0
0
0
% D
% Glu:
0
67
0
0
14
7
0
7
0
0
0
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
60
7
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
7
0
7
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
14
0
14
0
0
0
% I
% Lys:
0
14
0
67
0
0
14
0
0
0
0
0
0
0
7
% K
% Leu:
14
0
0
0
0
7
7
0
0
0
0
80
0
7
0
% L
% Met:
0
7
0
0
0
7
0
0
0
0
0
7
0
0
0
% M
% Asn:
7
0
94
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
0
74
0
0
0
0
0
0
0
87
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
67
0
0
0
7
0
0
0
0
% R
% Ser:
0
7
0
7
0
0
7
0
0
0
80
0
0
0
0
% S
% Thr:
0
0
0
7
0
0
0
74
7
7
0
0
0
0
87
% T
% Val:
0
0
0
0
0
0
0
0
0
67
7
0
94
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
74
0
7
0
7
0
0
0
20
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _