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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5B
All Species:
22.73
Human Site:
S621
Identified Species:
35.71
UniProt:
O60841
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60841
NP_056988.3
1220
138827
S621
E
K
R
R
L
E
H
S
K
N
V
N
T
E
K
Chimpanzee
Pan troglodytes
XP_001159716
1220
138677
S621
E
K
R
R
L
E
H
S
K
N
V
N
T
E
K
Rhesus Macaque
Macaca mulatta
XP_001103720
1526
171398
S927
E
K
R
R
L
E
H
S
K
N
V
N
T
E
K
Dog
Lupus familis
XP_851262
1220
138726
S621
E
K
R
R
L
E
H
S
K
N
V
N
T
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q05D44
1216
137597
G617
E
K
R
R
L
E
H
G
K
N
V
N
T
E
K
Rat
Rattus norvegicus
B2GUV7
1216
137668
G617
E
K
R
R
L
E
H
G
K
N
V
N
T
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507187
1282
144754
S683
E
K
R
R
I
E
N
S
K
N
V
N
T
E
K
Chicken
Gallus gallus
NP_001033585
1220
137737
S621
E
K
R
R
A
E
N
S
K
N
A
N
T
E
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923573
1166
130209
N578
E
S
E
D
E
E
D
N
K
E
S
S
N
K
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651974
1144
127185
E545
L
K
R
Q
A
E
A
E
K
K
R
S
T
D
E
Honey Bee
Apis mellifera
XP_392101
1028
116618
V493
I
R
E
S
T
K
H
V
K
G
F
D
E
K
K
Nematode Worm
Caenorhab. elegans
NP_497536
1074
120399
N481
Q
A
N
R
S
T
D
N
L
R
S
P
V
I
C
Sea Urchin
Strong. purpuratus
XP_001199006
1349
151384
E750
K
K
R
K
E
D
A
E
K
K
K
T
T
D
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177807
1294
142098
V669
A
V
K
A
T
P
E
V
E
D
A
T
R
T
K
Baker's Yeast
Sacchar. cerevisiae
P39730
1002
112250
S484
T
P
G
H
E
S
F
S
N
L
R
S
R
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
79.2
96
N.A.
91.6
90
N.A.
82.2
84.5
N.A.
64.3
N.A.
50.8
53.6
40.3
43.5
Protein Similarity:
100
99.7
79.7
97.8
N.A.
95.1
94.5
N.A.
87.6
90.5
N.A.
75.4
N.A.
66.7
67.7
61.1
62.7
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
80
N.A.
20
N.A.
33.3
20
6.6
26.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
86.6
N.A.
40
N.A.
60
46.6
20
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.3
39.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.9
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
7
14
0
14
0
0
0
14
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
7
0
7
14
0
0
7
0
7
0
14
0
% D
% Glu:
60
0
14
0
20
67
7
14
7
7
0
0
7
54
7
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% F
% Gly:
0
0
7
0
0
0
0
14
0
7
0
0
0
7
0
% G
% His:
0
0
0
7
0
0
47
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
0
0
7
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
7
67
7
7
0
7
0
0
80
14
7
0
0
14
67
% K
% Leu:
7
0
0
0
40
0
0
0
7
7
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
14
14
7
54
0
54
7
0
0
% N
% Pro:
0
7
0
0
0
7
0
0
0
0
0
7
0
0
0
% P
% Gln:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
67
60
0
0
0
0
0
7
14
0
14
0
0
% R
% Ser:
0
7
0
7
7
7
0
47
0
0
14
20
0
0
7
% S
% Thr:
7
0
0
0
14
7
0
0
0
0
0
14
67
7
7
% T
% Val:
0
7
0
0
0
0
0
14
0
0
47
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _