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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE8A
All Species:
19.7
Human Site:
Y291
Identified Species:
48.15
UniProt:
O60658
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60658
NP_002596.1
829
93304
Y291
K
E
W
Q
G
I
Y
Y
A
K
K
K
N
G
D
Chimpanzee
Pan troglodytes
XP_001163003
829
93316
Y291
K
E
W
Q
G
I
Y
Y
A
K
K
K
N
G
D
Rhesus Macaque
Macaca mulatta
XP_001086066
829
93245
Y291
K
E
W
Q
G
I
Y
Y
A
K
K
K
N
G
D
Dog
Lupus familis
XP_545870
839
95094
H300
K
E
W
Q
G
I
Y
H
A
K
K
K
N
G
D
Cat
Felis silvestris
Mouse
Mus musculus
O88502
823
93153
H287
K
E
W
Q
G
V
Y
H
T
Q
K
K
N
G
D
Rat
Rattus norvegicus
NP_942062
823
93250
H285
K
E
W
Q
G
V
Y
H
T
Q
K
K
N
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_413834
859
97059
S317
K
E
W
Q
G
M
Y
S
A
K
K
K
N
G
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001074096
817
91654
Y276
K
E
W
Q
G
V
Y
Y
A
K
K
K
N
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12252
1070
115060
G385
G
S
D
S
D
L
F
G
F
D
V
E
N
G
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9N2V9
760
84862
Y251
D
E
Q
R
V
V
Q
Y
V
N
R
A
Y
E
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.3
85.3
N.A.
78.7
78.7
N.A.
N.A.
77.4
N.A.
69.3
N.A.
21.3
N.A.
27.1
N.A.
Protein Similarity:
100
99.8
98.6
90.9
N.A.
87.5
88
N.A.
N.A.
85.6
N.A.
82.5
N.A.
36.6
N.A.
43.3
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
73.3
73.3
N.A.
N.A.
86.6
N.A.
93.3
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
93.3
N.A.
100
N.A.
33.3
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
60
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
10
0
0
0
0
10
0
0
0
0
80
% D
% Glu:
0
90
0
0
0
0
0
0
0
0
0
10
0
10
0
% E
% Phe:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
80
0
0
10
0
0
0
0
0
90
0
% G
% His:
0
0
0
0
0
0
0
30
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
40
0
0
0
0
0
0
0
0
0
% I
% Lys:
80
0
0
0
0
0
0
0
0
60
80
80
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
90
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
80
0
0
10
0
0
20
0
0
0
0
10
% Q
% Arg:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
10
0
10
0
0
0
10
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% T
% Val:
0
0
0
0
10
40
0
0
10
0
10
0
0
0
0
% V
% Trp:
0
0
80
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
80
50
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _