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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E2
All Species:
20.3
Human Site:
Y58
Identified Species:
31.9
UniProt:
O60573
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60573
NP_004837.1
245
28362
Y58
P
A
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
Chimpanzee
Pan troglodytes
XP_516153
236
27201
Y58
P
A
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545602
245
28254
Y58
P
A
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMB3
245
28244
Y58
P
A
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
Rat
Rattus norvegicus
P63074
217
25035
K52
L
W
F
F
K
N
D
K
S
K
T
W
Q
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232426
247
28450
Y58
P
A
E
H
P
L
Q
Y
N
Y
T
F
W
Y
S
Frog
Xenopus laevis
P48597
213
24616
D67
S
K
F
D
T
V
E
D
F
W
A
L
Y
N
H
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
D69
S
K
F
D
T
V
E
D
F
W
A
L
Y
N
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
K80
V
R
T
E
H
L
Y
K
H
P
L
M
N
V
W
Honey Bee
Apis mellifera
XP_623570
273
31794
S66
R
S
P
G
K
Q
P
S
I
Q
S
Y
D
Q
N
Nematode Worm
Caenorhab. elegans
Q22888
212
24566
E52
P
T
G
K
F
D
P
E
D
Y
A
S
Y
V
Q
Sea Urchin
Strong. purpuratus
NP_001077102
227
26298
F56
Q
Y
S
Y
C
V
W
F
S
R
R
T
P
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
F53
E
H
S
W
T
F
W
F
D
N
P
Q
S
K
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
R61
T
R
R
T
P
G
V
R
N
Q
S
Y
E
D
N
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
S57
P
A
V
D
K
S
E
S
W
S
D
L
L
R
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.4
N.A.
95.9
N.A.
98.3
28.9
N.A.
N.A.
87.8
29.3
29.3
N.A.
28.9
55.6
43.2
61.6
Protein Similarity:
100
92.2
N.A.
97.1
N.A.
99.5
49.3
N.A.
N.A.
91.5
50.6
49.3
N.A.
50.1
67.7
57.9
71.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
N.A.
100
0
0
N.A.
6.6
0
13.3
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
N.A.
100
26.6
26.6
N.A.
13.3
26.6
26.6
33.3
Percent
Protein Identity:
N.A.
32.6
N.A.
41.6
28.1
N.A.
Protein Similarity:
N.A.
53.8
N.A.
58.7
48.1
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
0
0
0
0
0
0
0
0
20
0
0
7
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
0
7
7
14
14
0
7
0
7
7
0
% D
% Glu:
7
0
34
7
0
0
20
7
0
0
0
0
7
0
0
% E
% Phe:
0
0
20
7
7
7
0
14
14
0
0
34
0
0
0
% F
% Gly:
0
0
7
7
0
7
0
0
0
0
0
0
0
7
0
% G
% His:
0
7
0
34
7
0
0
0
7
0
0
0
0
0
14
% H
% Ile:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% I
% Lys:
0
14
0
7
20
0
0
14
0
7
0
0
0
7
0
% K
% Leu:
7
0
0
0
0
40
0
0
0
0
7
20
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
7
0
0
40
7
0
0
7
14
27
% N
% Pro:
47
0
7
0
40
0
14
0
0
7
7
0
7
0
7
% P
% Gln:
7
0
0
0
0
7
34
0
0
14
0
7
7
7
7
% Q
% Arg:
7
14
7
0
0
0
0
7
0
7
7
0
0
7
0
% R
% Ser:
14
7
14
0
0
7
0
14
14
7
14
7
7
0
40
% S
% Thr:
7
7
7
7
20
0
0
0
0
0
40
7
0
0
0
% T
% Val:
7
0
7
0
0
20
7
0
0
0
0
0
0
14
0
% V
% Trp:
0
7
0
7
0
0
14
0
7
14
0
7
34
0
7
% W
% Tyr:
0
7
0
7
0
0
7
34
0
40
0
14
20
34
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _