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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E2
All Species:
22.12
Human Site:
T192
Identified Species:
34.76
UniProt:
O60573
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60573
NP_004837.1
245
28362
T192
K
T
A
S
D
Q
A
T
T
A
R
I
R
D
T
Chimpanzee
Pan troglodytes
XP_516153
236
27201
T192
K
T
A
S
D
Q
A
T
T
A
R
I
R
D
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545602
245
28254
T192
K
T
A
S
D
Q
A
T
T
A
L
I
R
D
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMB3
245
28244
T192
K
T
A
S
D
Q
A
T
T
A
R
I
R
D
T
Rat
Rattus norvegicus
P63074
217
25035
A175
T
E
C
E
N
R
D
A
V
T
H
I
G
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232426
247
28450
T192
K
T
A
S
D
Q
A
T
T
A
R
I
R
D
T
Frog
Xenopus laevis
P48597
213
24616
A171
T
E
F
E
N
K
D
A
V
T
H
I
G
R
V
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
A173
T
D
Y
E
N
K
D
A
I
V
H
I
G
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
A217
A
D
G
N
N
E
E
A
A
L
E
I
G
H
K
Honey Bee
Apis mellifera
XP_623570
273
31794
T184
K
T
A
S
D
Y
A
T
T
A
R
I
R
D
T
Nematode Worm
Caenorhab. elegans
Q22888
212
24566
V168
R
N
A
D
D
T
P
V
T
N
R
I
R
E
T
Sea Urchin
Strong. purpuratus
NP_001077102
227
26298
I184
R
T
A
S
D
N
S
I
N
I
R
V
R
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
A179
K
N
A
A
N
E
A
A
Q
V
S
I
G
K
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
A179
R
N
A
S
D
H
Q
A
V
M
G
L
R
D
S
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
L175
K
S
E
D
K
E
P
L
L
R
I
G
G
K
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.4
N.A.
95.9
N.A.
98.3
28.9
N.A.
N.A.
87.8
29.3
29.3
N.A.
28.9
55.6
43.2
61.6
Protein Similarity:
100
92.2
N.A.
97.1
N.A.
99.5
49.3
N.A.
N.A.
91.5
50.6
49.3
N.A.
50.1
67.7
57.9
71.4
P-Site Identity:
100
100
N.A.
93.3
N.A.
100
6.6
N.A.
N.A.
100
6.6
6.6
N.A.
6.6
93.3
46.6
53.3
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
20
N.A.
N.A.
100
20
20
N.A.
26.6
93.3
60
73.3
Percent
Protein Identity:
N.A.
32.6
N.A.
41.6
28.1
N.A.
Protein Similarity:
N.A.
53.8
N.A.
58.7
48.1
N.A.
P-Site Identity:
N.A.
26.6
N.A.
33.3
6.6
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
53.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
67
7
0
0
47
40
7
40
0
0
0
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
0
14
60
0
20
0
0
0
0
0
0
54
0
% D
% Glu:
0
14
7
20
0
20
7
0
0
0
7
0
0
7
0
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
7
0
0
0
0
0
0
0
7
7
40
0
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
20
0
0
7
0
% H
% Ile:
0
0
0
0
0
0
0
7
7
7
7
80
0
0
0
% I
% Lys:
54
0
0
0
7
14
0
0
0
0
0
0
0
14
7
% K
% Leu:
0
0
0
0
0
0
0
7
7
7
7
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
20
0
7
34
7
0
0
7
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
14
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
34
7
0
7
0
0
0
0
0
7
% Q
% Arg:
20
0
0
0
0
7
0
0
0
7
47
0
60
20
0
% R
% Ser:
0
7
0
54
0
0
7
0
0
0
7
0
0
0
7
% S
% Thr:
20
47
0
0
0
7
0
40
47
14
0
0
0
0
54
% T
% Val:
0
0
0
0
0
0
0
7
20
14
0
7
0
0
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _