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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AIRE All Species: 10.3
Human Site: S476 Identified Species: 28.33
UniProt: O43918 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43918 NP_000374.1 545 57727 S476 G L R C R S C S G D V T P A P
Chimpanzee Pan troglodytes XP_531580 545 57745 S476 G L R C R S C S G D V T P A P
Rhesus Macaque Macaca mulatta XP_001103602 548 57986 S476 G L R C R S C S G D M T P A P
Dog Lupus familis XP_544921 583 61257 D511 R C R S C S G D A G P A P G D
Cat Felis silvestris
Mouse Mus musculus Q9Z0E3 552 59024 T480 K S C S A D S T P T P G T P G
Rat Rattus norvegicus NP_001099849 547 58607 P475 C K S C S A E P T P T P G V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513786 602 66034 T530 E G L L P S N T S A L G A V K
Chicken Gallus gallus XP_427220 341 37367 P273 V P P L P R V P S G T W Q C S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001103484 511 56035 C439 G R T R C R N C S R S W G P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.1 89.2 74.4 N.A. 72 72 N.A. 52.1 32.8 N.A. 36.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.7 91 78.5 N.A. 78.9 78.4 N.A. 65.1 40.9 N.A. 54.6 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 20 N.A. 0 13.3 N.A. 6.6 0 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 6.6 20 N.A. 20 0 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 12 12 0 0 12 12 0 12 12 34 0 % A
% Cys: 12 12 12 45 23 0 34 12 0 0 0 0 0 12 0 % C
% Asp: 0 0 0 0 0 12 0 12 0 34 0 0 0 0 12 % D
% Glu: 12 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 45 12 0 0 0 0 12 0 34 23 0 23 23 12 23 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 12 12 0 0 0 0 0 0 0 0 0 0 0 0 12 % K
% Leu: 0 34 12 23 0 0 0 0 0 0 12 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 23 0 0 0 0 0 0 0 0 % N
% Pro: 0 12 12 0 23 0 0 23 12 12 23 12 45 23 45 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % Q
% Arg: 12 12 45 12 34 23 0 0 0 12 0 0 0 0 0 % R
% Ser: 0 12 12 23 12 56 12 34 34 0 12 0 0 0 12 % S
% Thr: 0 0 12 0 0 0 0 23 12 12 23 34 12 0 0 % T
% Val: 12 0 0 0 0 0 12 0 0 0 23 0 0 23 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 23 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _