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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AIRE
All Species:
10.61
Human Site:
S474
Identified Species:
29.17
UniProt:
O43918
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43918
NP_000374.1
545
57727
S474
G
T
G
L
R
C
R
S
C
S
G
D
V
T
P
Chimpanzee
Pan troglodytes
XP_531580
545
57745
S474
G
T
G
L
R
C
R
S
C
S
G
D
V
T
P
Rhesus Macaque
Macaca mulatta
XP_001103602
548
57986
S474
Q
T
G
L
R
C
R
S
C
S
G
D
M
T
P
Dog
Lupus familis
XP_544921
583
61257
S509
A
P
R
C
R
S
C
S
G
D
A
G
P
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0E3
552
59024
D478
R
C
K
S
C
S
A
D
S
T
P
T
P
G
T
Rat
Rattus norvegicus
NP_001099849
547
58607
A473
L
R
C
K
S
C
S
A
E
P
T
P
T
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513786
602
66034
S528
P
L
E
G
L
L
P
S
N
T
S
A
L
G
A
Chicken
Gallus gallus
XP_427220
341
37367
R271
C
L
V
P
P
L
P
R
V
P
S
G
T
W
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103484
511
56035
R437
P
N
G
R
T
R
C
R
N
C
S
R
S
W
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.1
89.2
74.4
N.A.
72
72
N.A.
52.1
32.8
N.A.
36.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.7
91
78.5
N.A.
78.9
78.4
N.A.
65.1
40.9
N.A.
54.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
20
N.A.
0
6.6
N.A.
6.6
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
6.6
13.3
N.A.
20
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
0
0
12
12
0
0
12
12
0
12
12
% A
% Cys:
12
12
12
12
12
45
23
0
34
12
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
12
0
12
0
34
0
0
0
% D
% Glu:
0
0
12
0
0
0
0
0
12
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
23
0
45
12
0
0
0
0
12
0
34
23
0
23
23
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
12
12
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
12
23
0
34
12
23
0
0
0
0
0
0
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% M
% Asn:
0
12
0
0
0
0
0
0
23
0
0
0
0
0
0
% N
% Pro:
23
12
0
12
12
0
23
0
0
23
12
12
23
12
45
% P
% Gln:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% Q
% Arg:
12
12
12
12
45
12
34
23
0
0
0
12
0
0
0
% R
% Ser:
0
0
0
12
12
23
12
56
12
34
34
0
12
0
0
% S
% Thr:
0
34
0
0
12
0
0
0
0
23
12
12
23
34
12
% T
% Val:
0
0
12
0
0
0
0
0
12
0
0
0
23
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
23
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _