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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XPNPEP2 All Species: 18.18
Human Site: S604 Identified Species: 33.33
UniProt: O43895 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43895 NP_003390.4 674 75625 S604 D R N L I D V S L L S P E H L
Chimpanzee Pan troglodytes XP_521256 675 75579 S605 D R N L I D V S L L S P E H L
Rhesus Macaque Macaca mulatta XP_001091201 674 75480 S604 D R N L I D V S L L S P E H L
Dog Lupus familis XP_549245 890 99571 S820 D G N L I D I S L L S S E H L
Cat Felis silvestris
Mouse Mus musculus Q6P1B1 623 69573 L564 L T F E P L T L V P I Q T K M
Rat Rattus norvegicus O54975 623 69639 L564 L T F E P L T L V P I Q T K M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521654 589 66878 G530 I G L N Y G H G T G H G V G N
Chicken Gallus gallus XP_421751 623 69997 L564 L T F E P L T L V P I Q T K M
Frog Xenopus laevis NP_001084745 621 69004 L562 L T F Q P I T L V P I Q A K M
Zebra Danio Brachydanio rerio NP_957326 702 79242 S630 D R N L I D T S L L N L E Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477409 613 68487 K554 N R G A L T F K T I T M C P K
Honey Bee Apis mellifera XP_392697 724 82990 N633 E P K L I D N N M L N P S H I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q07825 749 84906 S675 E Y G I R I E S D M L I K K A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 98 63.1 N.A. 40.2 39.6 N.A. 59 41 41 54.7 N.A. 39.3 36.1 N.A. N.A.
Protein Similarity: 100 96.8 98.9 68.3 N.A. 58.6 58.1 N.A. 68.4 58.9 60.2 68.9 N.A. 57.4 54.7 N.A. N.A.
P-Site Identity: 100 100 100 80 N.A. 0 0 N.A. 0 0 0 73.3 N.A. 6.6 40 N.A. N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 13.3 13.3 N.A. 0 13.3 13.3 80 N.A. 33.3 73.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 49.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 39 0 0 0 0 47 0 0 8 0 0 0 0 0 0 % D
% Glu: 16 0 0 24 0 0 8 0 0 0 0 0 39 0 0 % E
% Phe: 0 0 31 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 16 16 0 0 8 0 8 0 8 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 8 0 0 39 0 % H
% Ile: 8 0 0 8 47 16 8 0 0 8 31 8 0 0 8 % I
% Lys: 0 0 8 0 0 0 0 8 0 0 0 0 8 39 8 % K
% Leu: 31 0 8 47 8 24 0 31 39 47 8 8 0 0 39 % L
% Met: 0 0 0 0 0 0 0 0 8 8 0 8 0 0 31 % M
% Asn: 8 0 39 8 0 0 8 8 0 0 16 0 0 0 8 % N
% Pro: 0 8 0 0 31 0 0 0 0 31 0 31 0 8 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 31 0 8 0 % Q
% Arg: 0 39 0 0 8 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 47 0 0 31 8 8 0 0 % S
% Thr: 0 31 0 0 0 8 39 0 16 0 8 0 24 0 0 % T
% Val: 0 0 0 0 0 0 24 0 31 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _