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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA2
All Species:
18.18
Human Site:
Y451
Identified Species:
40
UniProt:
O43464
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43464
NP_037379.1
458
48841
Y451
G
R
E
T
L
T
L
Y
V
T
P
E
V
T
E
Chimpanzee
Pan troglodytes
XP_508084
598
64926
T590
G
N
E
D
I
M
I
T
V
I
P
E
E
I
D
Rhesus Macaque
Macaca mulatta
XP_001110803
458
48732
Y451
G
R
E
T
L
T
L
Y
V
T
P
E
V
T
E
Dog
Lupus familis
XP_532992
199
21668
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIY5
458
49330
Y451
G
S
E
T
L
T
L
Y
V
T
P
E
V
T
E
Rat
Rattus norvegicus
NP_001100069
458
49076
Y451
G
P
E
T
L
T
L
Y
V
T
P
E
V
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
N459
G
N
D
D
L
L
F
N
I
E
P
E
I
V
M
Frog
Xenopus laevis
NP_001088796
457
48812
S449
G
N
E
D
I
P
I
S
V
T
P
K
E
I
E
Zebra Danio
Brachydanio rerio
XP_001339411
294
31781
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
E449
N
K
E
R
V
T
L
E
V
I
P
E
E
A
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.9
99.1
41.7
N.A.
84.9
87.3
N.A.
N.A.
40.9
41
43.6
N.A.
42.3
N.A.
N.A.
N.A.
Protein Similarity:
100
52.5
99.1
42.5
N.A.
89.3
91.4
N.A.
N.A.
59.4
59.1
54.3
N.A.
59.3
N.A.
N.A.
N.A.
P-Site Identity:
100
33.3
100
0
N.A.
93.3
93.3
N.A.
N.A.
26.6
40
0
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
100
0
N.A.
93.3
93.3
N.A.
N.A.
46.6
60
0
N.A.
0
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
28
0
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
0
0
64
0
0
0
0
10
0
10
0
64
28
0
46
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
64
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
19
0
19
0
10
19
0
0
10
19
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% K
% Leu:
0
0
0
0
46
10
46
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% M
% Asn:
10
28
0
0
0
0
0
10
0
0
0
0
0
0
10
% N
% Pro:
0
10
0
0
0
10
0
0
0
0
73
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
19
0
10
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
37
0
46
0
10
0
46
0
0
0
37
0
% T
% Val:
0
0
0
0
10
0
0
0
64
0
0
0
37
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
37
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _