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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA2
All Species:
7.27
Human Site:
T32
Identified Species:
16
UniProt:
O43464
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43464
NP_037379.1
458
48841
T32
W
G
R
R
P
R
L
T
P
D
L
R
A
L
L
Chimpanzee
Pan troglodytes
XP_508084
598
64926
T161
R
G
Q
N
Q
R
V
T
G
V
R
G
A
A
T
Rhesus Macaque
Macaca mulatta
XP_001110803
458
48732
T32
W
G
R
R
P
R
L
T
P
D
L
R
A
L
L
Dog
Lupus familis
XP_532992
199
21668
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIY5
458
49330
A32
W
R
K
P
P
L
L
A
P
D
L
R
A
L
L
Rat
Rattus norvegicus
NP_001100069
458
49076
A32
W
R
K
G
P
L
L
A
P
D
L
R
A
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
N54
G
Y
V
P
D
R
C
N
C
C
L
I
C
A
A
Frog
Xenopus laevis
NP_001088796
457
48812
S31
C
P
A
R
C
D
P
S
S
C
S
P
A
P
T
Zebra Danio
Brachydanio rerio
XP_001339411
294
31781
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
R29
L
H
S
H
A
A
N
R
R
S
S
Q
L
A
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
G33
R
F
W
K
R
G
F
G
F
P
R
R
A
V
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.9
99.1
41.7
N.A.
84.9
87.3
N.A.
N.A.
40.9
41
43.6
N.A.
42.3
N.A.
N.A.
N.A.
Protein Similarity:
100
52.5
99.1
42.5
N.A.
89.3
91.4
N.A.
N.A.
59.4
59.1
54.3
N.A.
59.3
N.A.
N.A.
N.A.
P-Site Identity:
100
26.6
100
0
N.A.
66.6
66.6
N.A.
N.A.
13.3
13.3
0
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
100
0
N.A.
73.3
73.3
N.A.
N.A.
13.3
20
0
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
10
0
19
0
0
0
0
64
28
10
% A
% Cys:
10
0
0
0
10
0
10
0
10
19
0
0
10
0
0
% C
% Asp:
0
0
0
0
10
10
0
0
0
37
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
10
0
0
0
0
10
0
10
0
0
0
0
0
0
% F
% Gly:
10
28
0
10
0
10
0
10
10
0
0
10
0
0
0
% G
% His:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% I
% Lys:
0
0
19
10
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
0
19
37
0
0
0
46
0
10
37
37
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
0
0
10
10
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
19
37
0
10
0
37
10
0
10
0
10
0
% P
% Gln:
0
0
10
0
10
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
19
19
19
28
10
37
0
10
10
0
19
46
0
0
0
% R
% Ser:
0
0
10
0
0
0
0
10
10
10
19
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
28
0
0
0
0
0
0
19
% T
% Val:
0
0
10
0
0
0
10
0
0
10
0
0
0
10
0
% V
% Trp:
37
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _