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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF3
All Species:
22.42
Human Site:
T608
Identified Species:
37.95
UniProt:
O43395
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43395
NP_004689.1
683
77529
T608
R
I
K
W
D
E
Q
T
S
N
T
K
G
D
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101105
683
77496
T608
R
I
K
W
D
E
Q
T
S
N
T
K
G
D
D
Dog
Lupus familis
XP_860581
685
77562
T610
R
I
K
W
D
E
Q
T
S
N
T
K
G
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q922U1
683
77436
T608
R
I
K
W
D
E
Q
T
S
N
T
K
G
D
D
Rat
Rattus norvegicus
NP_001102029
637
72177
I560
N
P
A
K
K
F
K
I
E
A
N
A
G
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509322
682
76176
W607
L
M
L
H
R
I
K
W
R
E
Q
E
P
G
G
Chicken
Gallus gallus
Q5ZJ85
684
77367
T609
R
I
K
W
D
E
Q
T
S
N
T
K
G
E
D
Frog
Xenopus laevis
NP_001085273
679
76844
T604
R
I
K
W
D
E
Q
T
T
N
S
K
G
K
D
Zebra Danio
Brachydanio rerio
NP_991311
700
78843
L624
L
M
L
T
R
I
K
L
D
E
P
N
S
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649156
598
67364
L520
K
K
Y
R
R
L
M
L
T
R
I
K
W
E
E
Honey Bee
Apis mellifera
XP_392148
633
72356
M554
S
K
Y
K
R
L
M
M
N
R
I
K
W
E
E
Nematode Worm
Caenorhab. elegans
NP_499300
621
71178
W540
L
M
I
N
R
I
K
W
S
D
E
I
I
G
Q
Sea Urchin
Strong. purpuratus
XP_780513
572
64792
G496
M
L
H
R
I
K
W
G
E
D
K
R
S
K
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03338
469
55852
V396
C
K
F
Y
E
N
L
V
M
K
R
I
K
W
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.8
98.6
N.A.
99.5
90.7
N.A.
66.1
94.4
86.3
71.5
N.A.
48.3
52.2
35.8
49.6
Protein Similarity:
100
N.A.
100
98.8
N.A.
99.7
91.9
N.A.
78.9
97.9
93.5
83.8
N.A.
62.9
68.5
55.4
62.5
P-Site Identity:
100
N.A.
100
100
N.A.
100
6.6
N.A.
0
93.3
80
0
N.A.
6.6
6.6
6.6
0
P-Site Similarity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
20
100
93.3
13.3
N.A.
33.3
26.6
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
8
0
8
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
43
0
0
0
8
15
0
0
0
29
43
% D
% Glu:
0
0
0
0
8
43
0
0
15
15
8
8
0
22
15
% E
% Phe:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
0
0
50
15
8
% G
% His:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
43
8
0
8
22
0
8
0
0
15
15
8
0
0
% I
% Lys:
8
22
43
15
8
8
29
0
0
8
8
58
8
22
0
% K
% Leu:
22
8
15
0
0
15
8
15
0
0
0
0
0
0
8
% L
% Met:
8
22
0
0
0
0
15
8
8
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
0
8
0
0
8
43
8
8
0
0
8
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
8
0
8
0
0
% P
% Gln:
0
0
0
0
0
0
43
0
0
0
8
0
0
8
8
% Q
% Arg:
43
0
0
15
36
0
0
0
8
15
8
8
0
0
8
% R
% Ser:
8
0
0
0
0
0
0
0
43
0
8
0
15
0
0
% S
% Thr:
0
0
0
8
0
0
0
43
15
0
36
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
43
0
0
8
15
0
0
0
0
15
8
0
% W
% Tyr:
0
0
15
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _