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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC7A4
All Species:
8.79
Human Site:
S146
Identified Species:
19.33
UniProt:
O43246
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43246
NP_004164.2
635
68268
S146
G
Y
L
D
S
M
F
S
H
S
I
R
N
F
T
Chimpanzee
Pan troglodytes
XP_001168241
635
68228
S146
G
Y
L
D
S
M
F
S
H
G
I
R
N
F
T
Rhesus Macaque
Macaca mulatta
XP_001083909
635
68275
S146
G
Y
L
D
S
M
F
S
H
S
V
R
N
F
T
Dog
Lupus familis
XP_543561
635
68521
G146
G
Y
L
D
S
M
F
G
H
R
I
H
N
F
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLQ7
635
68332
N146
G
Y
L
D
A
I
F
N
H
S
I
R
N
F
T
Rat
Rattus norvegicus
P30823
624
67249
G145
E
L
I
G
K
P
I
G
E
F
S
R
Q
H
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
B3TP03
654
71198
G142
G
T
F
D
E
L
L
G
K
Q
I
S
H
F
F
Frog
Xenopus laevis
Q6DCE8
622
66913
V142
S
A
T
F
D
E
L
V
G
K
K
I
G
N
F
Zebra Danio
Brachydanio rerio
Q5PR34
640
69447
F152
E
K
F
C
K
M
Y
F
K
M
S
L
P
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649219
669
71839
G148
G
Y
V
D
S
M
L
G
G
W
I
G
N
T
T
Honey Bee
Apis mellifera
XP_624184
648
69772
G148
E
Y
V
D
S
L
A
G
G
S
I
S
N
Y
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.4
79
N.A.
81.4
42.2
N.A.
N.A.
40.6
41.2
40.1
N.A.
40.3
43.2
N.A.
N.A.
Protein Similarity:
100
99.6
99.2
88.9
N.A.
90.8
60.3
N.A.
N.A.
60
61.2
60.3
N.A.
59.3
62.8
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
80
N.A.
80
6.6
N.A.
N.A.
26.6
0
6.6
N.A.
53.3
40
N.A.
N.A.
P-Site Similarity:
100
93.3
100
80
N.A.
100
13.3
N.A.
N.A.
40
0
13.3
N.A.
60
66.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
10
0
10
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
73
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
28
0
0
0
10
10
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
19
10
0
0
46
10
0
10
0
0
0
55
19
% F
% Gly:
64
0
0
10
0
0
0
46
28
10
0
10
10
10
0
% G
% His:
0
0
0
0
0
0
0
0
46
0
0
10
10
10
0
% H
% Ile:
0
0
10
0
0
10
10
0
0
0
64
10
0
0
0
% I
% Lys:
0
10
0
0
19
0
0
0
19
10
10
0
0
0
0
% K
% Leu:
0
10
46
0
0
19
28
0
0
0
0
10
0
0
10
% L
% Met:
0
0
0
0
0
55
0
0
0
10
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
64
10
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
10
0
46
0
0
0
% R
% Ser:
10
0
0
0
55
0
0
28
0
37
19
19
0
0
10
% S
% Thr:
0
10
10
0
0
0
0
0
0
0
0
0
0
10
55
% T
% Val:
0
0
19
0
0
0
0
10
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
64
0
0
0
0
10
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _