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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NVL All Species: 17.27
Human Site: S134 Identified Species: 25.33
UniProt: O15381 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O15381 NP_002524.2 856 95051 S134 Y R K G N P D S V S N T P E M
Chimpanzee Pan troglodytes XP_514229 905 100536 S168 Y R K G N P D S V S N T P E M
Rhesus Macaque Macaca mulatta XP_001096627 856 94931 S134 Y R K G N P D S V S N T P E M
Dog Lupus familis XP_537239 955 104441 S207 Y R K G H P D S V T S T P E M
Cat Felis silvestris
Mouse Mus musculus Q9DBY8 855 94457 S133 Y R R G N S E S V S T T P K W
Rat Rattus norvegicus P46462 806 89330 H115 V K Y G K R I H V L P I D D T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512479 677 74669 D62 E V D G E I E D V L R K K A K
Chicken Gallus gallus
Frog Xenopus laevis P23787 805 89193 H115 V K Y G K R V H V L P I D D T
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 H115 V K Y G K R I H V L P I D D T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 P115 G K R V R I L P I D E S T E G
Honey Bee Apis mellifera XP_392923 818 90486 V115 R K A S E P E V V E N L Q Q K
Nematode Worm Caenorhab. elegans P54812 810 89622 K117 S A Q L E Y G K R V H V L P I
Sea Urchin Strong. purpuratus XP_785648 742 81148 Q117 T P L G G T P Q A T P M P S D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SS94 820 89986 R120 L R K R N M E R S V S S S P S
Baker's Yeast Sacchar. cerevisiae Q07844 837 93051 E130 E K P S L E E E L A K K N M M
Red Bread Mold Neurospora crassa Q7SGP2 1381 148356 I235 C E P V A Q G I L A P T T K I
Conservation
Percent
Protein Identity: 100 92.3 97.6 77.2 N.A. 87.8 35.9 N.A. 65.7 N.A. 35.9 35.7 N.A. 33.8 49.2 35.8 48.1
Protein Similarity: 100 93.1 98.5 83.1 N.A. 93.2 54.2 N.A. 72.1 N.A. 53.3 54.2 N.A. 54.2 65.1 54.2 60.5
P-Site Identity: 100 100 100 80 N.A. 60 13.3 N.A. 13.3 N.A. 13.3 13.3 N.A. 6.6 20 0 13.3
P-Site Similarity: 100 100 100 100 N.A. 80 26.6 N.A. 20 N.A. 26.6 26.6 N.A. 33.3 40 20 20
Percent
Protein Identity: N.A. N.A. N.A. 37.8 42.2 22.9
Protein Similarity: N.A. N.A. N.A. 57 61.5 38.1
P-Site Identity: N.A. N.A. N.A. 20 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 40 33.3 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 7 0 0 0 7 13 0 0 0 7 0 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 25 7 0 7 0 0 19 19 7 % D
% Glu: 13 7 0 0 19 7 32 7 0 7 7 0 0 32 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 63 7 0 13 0 0 0 0 0 0 0 7 % G
% His: 0 0 0 0 7 0 0 19 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 0 0 13 13 7 7 0 0 19 0 0 13 % I
% Lys: 0 38 32 0 19 0 0 7 0 0 7 13 7 13 13 % K
% Leu: 7 0 7 7 7 0 7 0 13 25 0 7 7 0 0 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 7 0 7 32 % M
% Asn: 0 0 0 0 32 0 0 0 0 0 25 0 7 0 0 % N
% Pro: 0 7 13 0 0 32 7 7 0 0 32 0 38 13 0 % P
% Gln: 0 0 7 0 0 7 0 7 0 0 0 0 7 7 0 % Q
% Arg: 7 38 13 7 7 19 0 7 7 0 7 0 0 0 0 % R
% Ser: 7 0 0 13 0 7 0 32 7 25 13 13 7 7 7 % S
% Thr: 7 0 0 0 0 7 0 0 0 13 7 38 13 0 19 % T
% Val: 19 7 0 13 0 0 7 7 63 13 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 32 0 19 0 0 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _