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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
35.76
Human Site:
Y51
Identified Species:
52.44
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Dog
Lupus familis
XP_858113
353
40330
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Rat
Rattus norvegicus
Q6P6W3
428
48802
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Frog
Xenopus laevis
Q6IRL9
428
48935
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
Y51
K
M
M
V
F
K
P
Y
K
A
S
Q
H
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
H55
K
M
E
I
Y
R
P
H
K
A
T
A
D
E
M
Honey Bee
Apis mellifera
XP_395811
433
49418
Y53
K
M
Q
I
Y
R
P
Y
R
A
S
T
H
D
M
Nematode Worm
Caenorhab. elegans
O17695
461
52119
F61
N
L
E
I
F
R
P
F
P
A
S
F
E
D
M
Sea Urchin
Strong. purpuratus
P56518
576
64060
H56
K
M
E
I
Y
R
P
H
K
A
V
M
E
E
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
N71
Q
M
Q
V
Y
R
P
N
P
A
R
E
R
E
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
H53
K
M
E
V
Y
R
P
H
K
A
Y
P
I
E
M
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
K67
K
M
E
I
Y
R
A
K
P
A
T
K
Q
E
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
N.A.
100
100
86.6
N.A.
33.3
60
40
33.3
P-Site Similarity:
100
100
100
0
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
80
86.6
66.6
73.3
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
26.6
N.A.
40
26.6
N.A.
P-Site Similarity:
N.A.
66.6
N.A.
73.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
94
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
7
63
0
% D
% Glu:
0
0
32
0
0
0
0
0
0
0
0
7
13
32
0
% E
% Phe:
0
0
0
0
57
0
0
7
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
19
0
0
0
0
57
0
0
% H
% Ile:
0
0
44
32
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
82
0
0
0
0
50
0
7
25
0
0
7
0
0
0
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% L
% Met:
0
88
7
0
0
0
0
0
0
0
0
7
0
0
88
% M
% Asn:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
88
0
19
0
0
7
0
0
0
% P
% Gln:
7
0
13
0
0
0
0
0
44
0
0
50
7
0
0
% Q
% Arg:
0
0
0
0
0
44
0
0
7
0
7
0
7
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
63
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
13
7
0
0
0
% T
% Val:
0
0
0
63
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
38
0
0
57
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _