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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
26.36
Human Site:
Y414
Identified Species:
38.67
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
Y414
P
E
A
P
N
E
F
Y
D
G
D
H
D
N
D
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
Y414
P
E
A
P
N
E
F
Y
D
G
D
H
D
N
D
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
Y414
P
E
A
P
N
E
F
Y
D
G
D
H
D
N
D
Dog
Lupus familis
XP_858113
353
40330
D340
E
A
P
N
E
F
Y
D
G
D
H
D
N
D
K
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
P410
N
Y
S
R
P
E
A
P
N
E
F
Y
D
G
D
Rat
Rattus norvegicus
Q6P6W3
428
48802
Y414
P
E
A
P
N
E
F
Y
D
G
D
H
D
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
Y414
P
E
A
A
N
E
F
Y
D
G
D
H
D
N
D
Frog
Xenopus laevis
Q6IRL9
428
48935
Y414
P
E
A
S
N
E
F
Y
D
G
D
H
D
N
D
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
Y414
P
E
A
A
N
E
F
Y
D
G
D
H
D
H
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
E417
K
R
I
V
P
E
N
E
Y
S
D
S
E
D
E
Honey Bee
Apis mellifera
XP_395811
433
49418
N416
D
K
I
I
E
P
A
N
E
Y
Y
S
G
E
K
Nematode Worm
Caenorhab. elegans
O17695
461
52119
D423
I
T
D
G
M
I
Q
D
D
G
D
F
Y
D
G
Sea Urchin
Strong. purpuratus
P56518
576
64060
D418
D
K
R
I
Q
R
D
D
E
F
S
D
S
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
R432
K
A
V
E
E
S
S
R
R
S
I
L
G
I
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
R406
V
R
A
D
Q
R
S
R
D
K
Q
I
Q
R
D
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
Q419
K
D
T
K
G
G
S
Q
Y
A
R
D
L
H
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
0
N.A.
20
100
N.A.
N.A.
93.3
93.3
86.6
N.A.
13.3
0
20
6.6
P-Site Similarity:
100
100
100
20
N.A.
40
100
N.A.
N.A.
93.3
93.3
93.3
N.A.
33.3
13.3
26.6
20
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
0
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
0
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
50
13
0
0
13
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
7
7
7
0
0
7
19
57
7
57
19
50
19
63
% D
% Glu:
7
44
0
7
19
57
0
7
13
7
0
0
7
13
7
% E
% Phe:
0
0
0
0
0
7
44
0
0
7
7
7
0
0
0
% F
% Gly:
0
0
0
7
7
7
0
0
7
50
0
0
13
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
44
0
13
0
% H
% Ile:
7
0
13
13
0
7
0
0
0
0
7
7
0
7
0
% I
% Lys:
19
13
0
7
0
0
0
0
0
7
0
0
0
0
19
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
7
44
0
7
7
7
0
0
0
7
38
0
% N
% Pro:
44
0
7
25
13
7
0
7
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
13
0
7
7
0
0
7
0
7
0
0
% Q
% Arg:
0
13
7
7
0
13
0
13
7
0
7
0
0
7
0
% R
% Ser:
0
0
7
7
0
7
19
0
0
13
7
13
7
0
0
% S
% Thr:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
7
0
7
7
0
0
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
7
44
13
7
7
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _