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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
26.06
Human Site:
Y387
Identified Species:
38.22
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
Y387
V
P
A
D
L
L
T
Y
D
R
T
D
E
A
D
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
Y387
V
P
A
D
L
L
T
Y
D
R
T
D
E
A
D
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
Y387
V
P
A
D
L
L
T
Y
D
R
T
D
E
A
D
Dog
Lupus familis
XP_858113
353
40330
D313
P
A
D
L
L
T
Y
D
R
T
D
E
A
D
A
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
D383
Q
I
H
D
V
P
A
D
L
L
T
Y
D
R
T
Rat
Rattus norvegicus
Q6P6W3
428
48802
Y387
V
P
A
D
L
L
T
Y
D
R
T
D
E
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
Y387
V
P
S
D
L
L
S
Y
D
R
T
D
E
P
D
Frog
Xenopus laevis
Q6IRL9
428
48935
Y387
V
P
S
D
I
L
N
Y
E
R
T
D
E
P
D
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
Y387
V
P
S
D
L
L
S
Y
E
R
P
D
E
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
E390
P
E
D
A
I
N
D
E
S
D
D
E
D
K
V
Honey Bee
Apis mellifera
XP_395811
433
49418
P389
V
P
C
D
A
L
S
P
E
E
E
R
Q
P
E
Nematode Worm
Caenorhab. elegans
O17695
461
52119
L396
P
E
D
A
L
S
A
L
N
D
D
S
L
I
A
Sea Urchin
Strong. purpuratus
P56518
576
64060
D391
P
E
D
A
I
P
D
D
S
D
A
E
D
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
D405
E
I
P
E
Q
D
E
D
Q
D
D
P
D
E
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
Q379
H
A
P
S
V
Q
M
Q
E
V
P
P
D
F
Y
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
N392
Y
A
P
S
V
Q
L
N
H
T
P
R
D
A
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
6.6
N.A.
13.3
100
N.A.
N.A.
80
66.6
73.3
N.A.
0
26.6
6.6
0
P-Site Similarity:
100
100
100
13.3
N.A.
26.6
100
N.A.
N.A.
93.3
86.6
93.3
N.A.
20
53.3
13.3
20
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
0
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
25
19
7
0
13
0
0
0
7
0
7
38
19
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
25
57
0
7
13
25
32
25
25
44
38
7
44
% D
% Glu:
7
19
0
7
0
0
7
7
25
7
7
19
44
13
13
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
7
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
13
0
0
19
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% K
% Leu:
0
0
0
7
50
50
7
7
7
7
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
7
7
7
0
0
0
0
0
0
% N
% Pro:
25
50
19
0
0
13
0
7
0
0
19
13
0
19
0
% P
% Gln:
7
0
0
0
7
13
0
7
7
0
0
0
7
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
7
44
0
13
0
7
7
% R
% Ser:
0
0
19
13
0
7
19
0
13
0
0
7
0
0
0
% S
% Thr:
0
0
0
0
0
7
25
0
0
13
44
0
0
0
7
% T
% Val:
50
0
0
0
19
0
0
0
0
7
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
7
44
0
0
0
7
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _