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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
28.18
Human Site:
Y282
Identified Species:
41.33
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
Y282
G
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
Y282
G
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
Y282
G
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
Dog
Lupus familis
XP_858113
353
40330
V208
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
L
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
E278
L
S
I
R
G
H
G
E
C
V
E
Y
V
K
S
Rat
Rattus norvegicus
Q6P6W3
428
48802
Y282
G
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
Y282
G
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
Frog
Xenopus laevis
Q6IRL9
428
48935
Y282
G
H
G
E
C
V
Q
Y
V
K
S
F
N
I
P
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
F282
G
H
G
E
C
V
E
F
V
K
G
F
K
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
F285
G
H
G
K
C
V
E
F
V
K
K
Y
N
L
P
Honey Bee
Apis mellifera
XP_395811
433
49418
F284
G
H
G
E
C
V
K
F
V
R
D
L
N
V
P
Nematode Worm
Caenorhab. elegans
O17695
461
52119
F291
G
H
G
E
C
A
R
F
F
R
S
Y
N
V
P
Sea Urchin
Strong. purpuratus
P56518
576
64060
F286
G
H
A
K
C
V
E
F
M
K
Q
Y
N
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Y300
G
H
A
E
C
V
R
Y
M
R
S
F
N
V
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
S274
R
L
G
C
F
N
L
S
I
D
G
H
A
E
C
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
S287
R
L
G
C
F
N
L
S
M
E
G
H
A
N
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
0
N.A.
0
100
N.A.
N.A.
100
93.3
80
N.A.
66.6
60
53.3
53.3
P-Site Similarity:
100
100
100
0
N.A.
6.6
100
N.A.
N.A.
100
100
86.6
N.A.
93.3
86.6
80
86.6
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
66.6
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
86.6
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
0
0
7
0
0
0
0
0
0
13
0
0
% A
% Cys:
0
0
0
19
75
0
0
0
7
0
0
0
0
0
13
% C
% Asp:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
0
% D
% Glu:
0
0
7
63
0
7
50
7
0
7
7
0
0
7
0
% E
% Phe:
0
0
0
0
13
0
0
32
7
0
7
50
0
0
0
% F
% Gly:
75
7
75
0
7
0
7
0
0
0
19
0
0
0
0
% G
% His:
7
75
0
0
0
7
0
0
0
0
0
13
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
7
0
0
0
7
44
0
% I
% Lys:
0
0
0
13
0
0
7
0
7
57
7
0
7
7
0
% K
% Leu:
7
13
0
0
0
0
13
0
0
0
0
7
0
13
7
% L
% Met:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
13
0
0
0
0
0
7
69
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
75
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% Q
% Arg:
13
0
0
7
0
0
13
0
0
19
0
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
0
13
0
7
50
0
0
0
7
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
7
69
0
7
57
7
0
0
7
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
44
0
0
0
25
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _