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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
46.06
Human Site:
Y232
Identified Species:
67.56
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
Y232
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
Y232
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
Y232
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
Dog
Lupus familis
XP_858113
353
40330
K158
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
I
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
D228
V
P
L
R
D
G
I
D
D
Q
S
Y
K
H
L
Rat
Rattus norvegicus
Q6P6W3
428
48802
Y232
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
Y232
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
Frog
Xenopus laevis
Q6IRL9
428
48935
Y232
D
G
I
D
D
Q
S
Y
R
H
L
F
Q
P
V
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
Y232
D
G
I
D
D
Q
S
Y
R
Q
L
F
Q
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
Y235
D
G
M
D
D
D
A
Y
E
S
I
F
V
P
I
Honey Bee
Apis mellifera
XP_395811
433
49418
Y234
E
G
I
D
D
T
S
Y
V
Q
V
F
K
P
V
Nematode Worm
Caenorhab. elegans
O17695
461
52119
Y241
D
G
I
T
D
V
S
Y
Q
S
I
F
K
P
I
Sea Urchin
Strong. purpuratus
P56518
576
64060
Y236
D
G
I
D
D
E
S
Y
D
K
I
F
K
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Y250
D
G
I
D
D
E
S
Y
Q
S
L
F
K
P
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
P224
K
F
Y
A
I
N
V
P
L
K
D
G
I
D
D
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
P237
K
N
Y
A
V
N
V
P
L
R
D
G
I
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
6.6
N.A.
6.6
100
N.A.
N.A.
100
93.3
86.6
N.A.
46.6
60
53.3
60
P-Site Similarity:
100
100
100
13.3
N.A.
33.3
100
N.A.
N.A.
100
100
93.3
N.A.
80
80
80
86.6
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
66.6
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
13
0
0
7
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
69
0
7
75
82
7
0
7
13
0
13
0
0
13
13
% D
% Glu:
7
0
0
0
0
13
0
0
7
0
0
0
0
0
0
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
7
75
0
0
0
% F
% Gly:
7
75
0
0
0
7
0
0
0
0
0
13
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
38
0
0
0
7
0
% H
% Ile:
0
7
69
0
7
0
7
0
0
0
19
0
13
0
32
% I
% Lys:
13
0
0
0
0
0
0
7
32
13
0
0
32
0
0
% K
% Leu:
0
0
7
0
0
0
0
0
13
7
50
0
0
0
7
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
13
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
13
0
0
0
0
7
75
0
% P
% Gln:
0
0
0
0
7
44
0
0
13
19
0
7
44
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
13
7
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
7
69
0
0
19
7
0
0
0
0
% S
% Thr:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
7
0
0
0
7
7
13
0
7
0
7
0
7
7
50
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
13
0
0
0
7
75
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _