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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC3
All Species:
51.52
Human Site:
S111
Identified Species:
75.56
UniProt:
O15379
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15379
NP_003874.2
428
48848
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Chimpanzee
Pan troglodytes
XP_001151110
445
50691
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Rhesus Macaque
Macaca mulatta
XP_001093955
450
51361
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Dog
Lupus familis
XP_858113
353
40330
D49
Y
K
K
M
I
I
C
D
I
A
I
N
W
A
G
Cat
Felis silvestris
Mouse
Mus musculus
O88895
424
48346
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Rat
Rattus norvegicus
Q6P6W3
428
48802
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P56520
428
48883
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Frog
Xenopus laevis
Q6IRL9
428
48935
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
L
L
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
S115
C
Q
L
S
A
G
G
S
V
A
A
A
V
K
L
Honey Bee
Apis mellifera
XP_395811
433
49418
S113
C
S
M
Y
T
G
A
S
L
E
G
A
T
K
L
Nematode Worm
Caenorhab. elegans
O17695
461
52119
S121
C
Q
L
S
S
G
G
S
L
A
A
A
T
K
L
Sea Urchin
Strong. purpuratus
P56518
576
64060
S116
C
Q
L
S
S
G
G
S
V
A
G
A
V
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
S131
C
Q
T
Y
A
G
A
S
V
G
G
A
V
K
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
T113
C
Q
L
Y
A
G
G
T
I
D
A
A
R
R
L
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
S127
C
S
I
S
G
G
G
S
M
E
G
A
A
R
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.5
94.4
82.4
N.A.
98.8
99.7
N.A.
N.A.
97.4
94.8
92
N.A.
48.5
70.4
52.4
45.8
Protein Similarity:
100
95.9
94.8
82.4
N.A.
99
100
N.A.
N.A.
98.3
97.4
96
N.A.
66.2
84.7
70.7
60.2
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
33.3
80
46.6
40
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
N.A.
100
93.3
100
N.A.
46.6
93.3
60
60
Percent
Protein Identity:
N.A.
46.7
N.A.
57.2
54.9
N.A.
Protein Similarity:
N.A.
64.3
N.A.
75.4
74.1
N.A.
P-Site Identity:
N.A.
46.6
N.A.
33.3
46.6
N.A.
P-Site Similarity:
N.A.
60
N.A.
53.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
19
0
63
0
0
25
19
94
7
7
0
% A
% Cys:
94
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
7
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
7
94
32
0
0
7
75
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
7
7
0
0
13
0
7
0
0
0
0
% I
% Lys:
0
7
7
0
0
0
0
0
0
0
0
0
0
32
0
% K
% Leu:
0
0
25
0
0
0
0
0
63
0
0
0
0
7
88
% L
% Met:
0
0
7
7
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
32
0
0
0
0
0
0
0
50
0
0
0
44
0
% Q
% Arg:
0
0
50
0
0
0
0
0
0
0
0
0
7
13
0
% R
% Ser:
0
63
0
25
13
0
0
88
0
0
0
0
0
0
0
% S
% Thr:
0
0
7
0
57
0
0
7
0
0
0
0
63
0
0
% T
% Val:
0
0
0
0
0
0
0
0
19
0
0
0
19
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
7
0
0
69
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _