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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3D
All Species:
33.03
Human Site:
Y335
Identified Species:
55.9
UniProt:
O15371
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15371
NP_003744.1
548
63973
Y335
L
R
M
G
K
E
R
Y
N
F
P
N
P
N
P
Chimpanzee
Pan troglodytes
XP_001158987
547
63723
Y335
L
R
M
G
K
E
R
Y
N
F
P
N
P
N
P
Rhesus Macaque
Macaca mulatta
XP_001083790
547
63709
Y335
L
R
M
G
K
E
R
Y
N
F
P
N
P
N
P
Dog
Lupus familis
XP_850595
548
63914
Y335
L
R
M
G
K
E
R
Y
N
F
P
N
P
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Q6AYK8
548
63970
Y335
L
R
M
G
R
E
R
Y
N
F
P
N
P
N
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506069
668
76273
Y335
L
R
M
G
K
D
R
Y
K
F
P
N
P
N
P
Chicken
Gallus gallus
XP_001234643
699
80199
Y489
L
R
M
G
K
E
K
Y
K
F
P
N
P
N
P
Frog
Xenopus laevis
Q7ZTM9
550
63926
H338
L
R
M
G
K
E
K
H
T
F
P
N
P
N
P
Zebra Danio
Brachydanio rerio
Q6TH15
552
64071
Y338
L
R
M
G
G
E
R
Y
K
F
P
N
P
N
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCK0
560
63779
P341
L
K
T
G
D
Q
E
P
K
Y
K
F
E
E
S
Honey Bee
Apis mellifera
XP_393057
562
64634
Y351
L
K
S
N
E
P
R
Y
K
F
E
E
G
N
P
Nematode Worm
Caenorhab. elegans
P30642
570
64271
N355
R
R
Q
V
V
K
R
N
D
A
G
F
T
F
K
Sea Urchin
Strong. purpuratus
XP_796913
549
63524
F335
L
K
M
G
G
E
K
F
K
F
E
V
D
N
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P56820
591
66706
E359
L
V
R
D
G
K
K
E
T
F
D
E
A
N
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.2
99
N.A.
N.A.
98.9
N.A.
73.8
72.5
89.4
90.4
N.A.
56.7
60.5
45.7
63.2
Protein Similarity:
100
99.4
99.4
99.8
N.A.
N.A.
99.8
N.A.
77.4
76.3
96.7
96.7
N.A.
73.3
77
63.5
82.3
P-Site Identity:
100
100
100
100
N.A.
N.A.
93.3
N.A.
86.6
86.6
80
86.6
N.A.
13.3
40
13.3
46.6
P-Site Similarity:
100
100
100
100
N.A.
N.A.
100
N.A.
93.3
93.3
93.3
86.6
N.A.
33.3
53.3
26.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
40.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
8
0
0
8
0
8
0
8
0
0
% D
% Glu:
0
0
0
0
8
65
8
8
0
0
15
15
8
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
86
0
15
0
8
0
% F
% Gly:
0
0
0
79
22
0
0
0
0
0
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
22
0
0
50
15
29
0
43
0
8
0
0
0
8
% K
% Leu:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
72
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
8
36
0
0
65
0
86
0
% N
% Pro:
0
0
0
0
0
8
0
8
0
0
65
0
65
0
86
% P
% Gln:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
72
8
0
8
0
65
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
8
0
0
0
0
0
15
0
0
0
8
0
0
% T
% Val:
0
8
0
8
8
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
65
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _